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Synthesis, characterization, crystal structure and DNA-binding study of four cadmium(II) pyridine-carboxamide complexes

Journal of Chemical Sciences volume 129, pages 45–55 (2017)Cite this article

Abstract

Treatment of perchlorate or nitrate salt of cadmium(II) with carboxamide derivatives (L) generated four novel mononuclear metal complexes, represented as [Cd(L )4](ClO4)2 (1a and 1b) and [Cd(L)2(ONO2)2] (2a and 2b) in appreciable yields (L = L 1 = N-(furan-2-ylmethyl)-2-pyridine carboxamide and L = L 2 = N-(thiophen-2-ylmethyl)-2-pyridine carboxamide). The complexes have been characterized by FT-IR, UV-Visible, elemental analysis and single crystal X-ray crystallographic analysis which revealed eight coordinated cadmium ions, but in different coordination environments, depending on the counter anion used. In addition, electronic absorption, fluorescence spectroscopy and viscosity measurements revealed a significant interaction of the four complexes with CT-DNA via intercalative/groove binding mode. The intrinsic binding constant K b obtained varies from 0.4 × 10 4 to 1.11 × 10 5 M−1. The results suggest that neutral complexes 2a and 2b bind to DNA in an intercalative mode. On the other hand, cationic complexes 1a and 1b bind with DNA via weak electrostatic/covalent interaction.

Synthesis and characterization of four mononuclear eight coordinated cadmium(II) complexes with newly explored carboxamide derivatives and study of interaction with calf-thymus DNA are reported. The results suggest that neutral complexes 2a and 2b bind to DNA in an intercalative mode. On the other hand, cationic complexes 1a and 1b interact with DNA via weak intercalative or groove binding mode.

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Acknowledgements

Financial support from the Council of Scientific and Industrial Research (CSIR), New Delhi, India [CSIR Scheme No. 01(2685)/12/EMR-II dated 03-10-2012] is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Chemistry, Burdwan University, Golapbag, Burdwan, West Bengal, 713 104, India

    BIPLAB MONDAL, BUDDHADEB SEN, SANDIPAN SARKAR & PABITRA CHATTOPADHYAY

  2. Department of Chemical and Pharmaceutical Sciences, Via Licio Giorgieri 1, 34127, Trieste, Italy

    ENNIO ZANGRANDO

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  1. BIPLAB MONDAL
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  2. BUDDHADEB SEN
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  3. SANDIPAN SARKAR
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Correspondence to PABITRA CHATTOPADHYAY.

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Supplementary Information (SI)

Crystallographic data for the structural analyses of complexes 1a and 2b have been deposited with the Cambridge Crystallographic Data Centre bearing the CCDC Nos. 1438356 and 1438357, respectively. Copies of this information are available on request at free of charge from CCDC, Union Road, Cambridge, CB21EZ, UK (fax: + 44-1223-336-033; e-mail: deposit@ccdc.ac.uk or http://www.ccdc.cam.ac.uk). NMR spectra (Figures S1–S4), plots of DNA binding experiments for complex 2b from the absorbance and emission study and its comparison with the complex 1 and other reported cadmium(II) complexes, and CIF files of complexes 1a and 2b are available at http://www.ias.ac.in/chemsci.

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MONDAL, B., SEN, B., SARKAR, S. et al. Synthesis, characterization, crystal structure and DNA-binding study of four cadmium(II) pyridine-carboxamide complexes. J Chem Sci 129, 45–55 (2017). https://doi.org/10.1007/s12039-016-1215-9

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  • DOI: https://doi.org/10.1007/s12039-016-1215-9

Keywords

  • Cadmium(II) complex
  • carboxamide ligand
  • crystal structures
  • DNA binding study.