Skip to main content
SpringerLink
Log in

Mn(II) complexes with bipyridine, phenanthroline and benzoic acid: Biological and catalase-like activity

  • Published:
Journal of Chemical Sciences Aims and scope Submit manuscript

Abstract

Five mononuclear Mn(II) complexes, [Mn(phen)2(ClO4)2] (1), [Mn(phen)3](ClO4)2(H2CO3)2(2), [Mn(bipy)2(ClO4)2] (3), [Mn(bipy)3](ClO4)2) (4), and Mn(phen)2(ba)(H2O)](ClO4)(CH3OH) (5), where bipy = 2,2’-bipyridine, phen = 1,10-phenanthroline, and ba = benzoic acid were prepared and characterized by X-ray, IR and UV-Vis spectroscopies, and their catalase-like and biological activities were studied. The presence of two different types and the number of chelating NN-donor neutral ligands allowed for analysis of their effects on the catalase and biological activities. It was observed that the presence and number of phen ligands improved the activity more than the bipy ligand. Complexes 1 and 2, which contain more basic phen ligands, disproportionate H2O2 faster than complexes 3 and 4, which contain less basic bipy ligands. The in vitro antimicrobial activities of all the complexes were also tested against seven bacterial strains by microdilution tests. All the bacterial isolates demonstrated sensitivity to the complexes and the antifungal (anticandidal) activities of the Mn(II) complexes were remarkably higher than the reference drug ketoconazole.

Five Mn(II) complexes of 2,2´-bipyridine / 1,10´-phenanthroline and benzoic acid have been synthesized and characterized through X-ray crystallography. The complexes showed good biological and catalase activity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Scheme 1.
Figure 1
Figure 2
Figure 3
Figure 4

Similar content being viewed by others

References

  1. Ronconi L and Sadler P J 2007 Coord. Chem. Rev. 251 1633

    Article  CAS  Google Scholar 

  2. Storr T, Thompson K H and Orvi C 2006 Chem. Soc. Rev. 35 534

    Article  CAS  Google Scholar 

  3. Guo Z and Sadler P J 1999 Angew. Chem. Int. Ed. 38 1512

    Article  CAS  Google Scholar 

  4. Lippert B 1999 In Cisplatin: Chemistry and Biochemistry of a Leading Anticancer Drug (New York: John Wiley)

    Book  Google Scholar 

  5. Tapiero H and Tew K D 2003 Biomed. Pharmacother. 57 399

    Article  CAS  Google Scholar 

  6. Biswas B, Kole N, Patra M, Shampa Dotta S and Ganguly M 2013 J. Chem. Sci. 125 1445

    Article  CAS  Google Scholar 

  7. Patel M N, Joshi H N and Patel C R 2014 J. Chem. Sci. 126 739

    Article  CAS  Google Scholar 

  8. Fukuda Y and Sone K 1970 Bull. Chem. Soc. Jpn. 43 556

    Article  CAS  Google Scholar 

  9. Bailey N A, Fenton D E, Franklin M V and Hall M 1980 J. Chem. Soc. Dalton. Trans. 984

  10. Madalan A M, Kravtsov V C, Pajic D, Zadro K, Simonov Y A, Stanica N, Ouahab L, Lipkowski J and Andruh M 2004 Inorg. Chim. Acta 357 4151

    Article  CAS  Google Scholar 

  11. Paulovicova A, El-Ayaan U and Fukuda Y 2001 Inorg. Chim. Acta 321 56

    Article  CAS  Google Scholar 

  12. Triller M U, Hsieh W Y, Pecoraro V L, Rompel A and Krebs B 2002 Inorg. Chem. 4 5544

    Article  Google Scholar 

  13. Wu A J, Penner-Hahn J E and Pecoraro V L 2004 Chem. Rev. 104 903

    Article  CAS  Google Scholar 

  14. Reddig N, Pursche D, Kloskowski M, Slinn C, Baldeau S M and Rompel A 2004 Eur. J. Inorg. Chem. 879

  15. Signorella S, Rompel A, Buldt-Karentzopoulos K, Krebs B, Pecoraro V L and Tuchagues J P 2007 Inorg. Chem. 46 10864

    Article  CAS  Google Scholar 

  16. Signorella S and Hureau C 2012 Coord. Chem. Rev. 256 1229

    Article  CAS  Google Scholar 

  17. Biava H, Palopoli C, Duhayon C, Tuchagues J P and Signorella S 2009 Inorg. Chem. 48 3205

    Article  CAS  Google Scholar 

  18. Biju A R and Rajasekharan M V 2011 Inorg. Chim. Acta 372 275

    Article  CAS  Google Scholar 

  19. Vázquez-Fernández M A, Bermejo M R, Fernández-García M I, González-Riopedre G, Rodríguez-Doutón M J and Maneiro M J 2011 Inorg. Biochem. 105 1538

    Article  Google Scholar 

  20. Malik G S, Singh S P and Bisht N P S 1980 Curr. Sci. 49 298

    CAS  Google Scholar 

  21. Coyle B, Kinsella P, McCann M, Devereux M, O’Connor R, Clynes M and Kavanagh K 2004 Toxicol. in Vitro 18 63

    Article  CAS  Google Scholar 

  22. De Vizcaya-Ruiz A, Rivero-Muller A, Ruiz-Ramirez L, Kass G, Kelland L R, Orr R M and Dobrota M 2000 Toxicol. in Vitro 14 1

    Article  CAS  Google Scholar 

  23. Gurumoorthy P, Ravichandran J and Rahiman A K 2014 J. Chem. Sci. 126 783

    Article  CAS  Google Scholar 

  24. Gulea A, Poirier D, Roy J, Stavila V, Bulimestru I, Tapcov V, Birca M and Popovschi L 2008 J. Enzyme Inhib. Med. Chem. 23 806

    Article  CAS  Google Scholar 

  25. Qaiyumi S 2007 In Antimicrobial Susceptibility Testing Protocols R Schwalbe, L Steele-Moore and A C Goodwin (Eds.) (London: CRC Press)

  26. SMART 2000 (Bruker Analytics l X-ray Systems Inc: Madison WI 53719 USA)

  27. Sheldrick G M 1997 SHELXS-97 Program for crystal structure solution (Gottingen: University of Gottingen)

  28. Sheldrick G M 1997 SHELXL-97 Program for crystal structure refinement (University of Gottingen: Gottingen)

  29. Spek A L 2005 PLATON - A Multipurpose Crystallographic Tool (The Netherlands: Utrecht University)

  30. Wickenden A E and Krause R 1965 Inorg. Chem. 4 404

    Article  CAS  Google Scholar 

  31. Hathaway B J and Underhill A E 1961 J. Chem. Soc. 3091

  32. Nakamoto K 1986 In Infrared and Raman Spectra of Inorganic and Coordination Compounds 4th edn. (New York: Wiley–Interscience)

  33. Gurdip S, Inder P S K, Dinesh K, Udai P S and Nidhi G 2009 Inorg. Chim. Acta 362 4091

    Article  Google Scholar 

  34. McCann S, McCann M, Casey M T, Jackman M, Devereux M and McKee V 1998 Inorg. Chim. Acta 279 24

    Article  CAS  Google Scholar 

  35. Zhenyu L, Duanjun X, Jingjing N, Zhiyong W, Jingyun W and Chiang M Y 2002 J. Coord. Chem. 55 1155

    Article  Google Scholar 

  36. Rodriguez-Martin Y, Javier G P and Catalana R P 1999 Acta Cryst. C55 186

    CAS  Google Scholar 

  37. Malinowski T J, Kravtsov V C, Simonov Y A, Lipkowski J and Bologa O A 1996 J. Coord. Chem. 37 187

    Article  CAS  Google Scholar 

  38. Zhao J, Zheng X G and Hu Z Z 2009 Acta Cryst. E65 m1642

    Google Scholar 

  39. Pan T T and Xu D 2005 Acta Cryst. E61 m740

    Google Scholar 

  40. Kani I and Kurtça M 2012 Turk. J. Chem. 36 827

    CAS  Google Scholar 

  41. Cotton F A and Wilkinson G 1972 In Advanced Inorganic Chemistry (New York: John Wiley and Sons)

    Google Scholar 

  42. Paavo O L and Eva L 1988 Acta Cryst C44 463

    Google Scholar 

  43. Li Z Y, Xu D J, Nie J J, Wu Z Y, Wu J Y and Chiang M 2002 J. Coord. Chem. 55 1155

    Article  CAS  Google Scholar 

  44. Veidis M V, Dockum B, Charron F F, Reiff W M and Brennan T F 1981 Inorg. Chim. Acta 53 L197

    Article  CAS  Google Scholar 

  45. Boelrijk A E. and Dismukes G C 2000 Inorg. Chem. 39 3020

    Article  CAS  Google Scholar 

  46. Tweedy B G 1964 Phytopathology 55 910

    Google Scholar 

  47. Seven M J and Johnson L A 1960 In Metal Binding in Medicine 4th ed (Philadelphia PA: Lippincott)

  48. Chohan Z H and Supuran C T 2005 Appl. Organometal. Chem. 19 1207

    Article  CAS  Google Scholar 

  49. Chohan Z H, Arif M, Akhtar M A and Supuran C 2006 Bioinorg. Chem. Appl. 1

  50. Raman N, Raja S J and Sakthivel A 2009 J. Coord. Chem. 62 691

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors are grateful to Anadolu University and the Medicinal Plants and Medicine research Centre of Anadolu University, Eskişehir, Turkey, for the use of X-ray Diffractometer. This work was supported by BAP (1106F1123) funded by Anadolu University.

Author information

Authors and Affiliations

  1. Department of Chemistry, Faculty of Sciences, Anadolu University, Eskişehir, Turkey

    IBRAHIM KANI & ÖZLEM ATLIER

  2. Department of Biology, Faculty of Sciences, Anadolu University, Eskişehir, Turkey

    KIYMET GÜVEN

Authors
  1. IBRAHIM KANI
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. ÖZLEM ATLIER
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. KIYMET GÜVEN
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to IBRAHIM KANI.

Additional information

Supplementary Information (SI)

CCDC 808526, 848864, 848417, 798813 and 827692 contain the supplementary crystallographic data for complexes 1 – 5, respectively. These data can be obtained free of charge via http://www.ccdc.cam.ac.uk/conts/retrieving.html, or from the Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, UK; fax: (+44) 1223-336-033; or e-mail: deposit@ccdc.cam.ac.uk. FTIR spectra and UV-Vis spectra are available in Supplementary Information at www.ias.ac.in.chemsci.

Electronic supplementary material

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

KANI, I., ATLIER, Ö. & GÜVEN, K. Mn(II) complexes with bipyridine, phenanthroline and benzoic acid: Biological and catalase-like activity. J Chem Sci 128, 523–536 (2016). https://doi.org/10.1007/s12039-016-1050-z

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12039-016-1050-z

Keywords

Search

Navigation