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Facile synthesis of Graphene Oxide/Double-stranded DNA composite liquid crystals and Hydrogels

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Abstract

Investigation of the interactions between graphene oxide (GO) and biomolecules is very crucial for the development of biomedical applications based on GO. This study reports the first observation of the spontaneous formation of self-assembled liquid crystals and three-dimensional hydrogels of graphene oxide with double-stranded DNA by simple mixing in an aqueous buffer media without unwinding double-stranded DNA to single-stranded DNA. The GO/dsDNA hydrogels have shown controlled porosity by changing the concentration of the components. The strong binding between dsDNA and graphene is proved by Raman spectroscopy.

The spontaneous formation of composite liquid crystals (LCs) and porosity-controlled hydrogels of GO with double stranded DNA (dsDNA) in aqueous solution are reported for the first time. The simple self-assembled materials, dsDNA/GO may open new windows in biosesning and tissue engineering applications.

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Acknowledgements

Our sincere thanks to Dr. Ravula Thirupathi (University of Michigan) for his kind help in the schematic diagrams as well as in the discussion part. We also acknowledge Council of Scientific and Industrial Research (CSIR), India for the financial support by providing research fellowships.

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    Authors and Affiliations

    1. Department of Materials Engineering, Indian Institute of Science, Bangalore, 560 012, India

      RAJENDRA KURAPATI & ASHOK M RAICHUR

    2. Department of Chemical Technology, University of Johannesburg, P.O. Box 17011, Doornfontein, 2028, South Africa

      ASHOK M RAICHUR

    3. NMR Research Centre and Solid State and Structural Chemistry Unit, Indian Institute of Science, Bangalore, 560 012, India

      U VENKATESWARA REDDY & N SURYAPRAKASH

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    1. RAJENDRA KURAPATI
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    2. U VENKATESWARA REDDY
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    Corresponding authors

    Correspondence to ASHOK M RAICHUR or N SURYAPRAKASH.

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    Supplementary Information (SI)

    The synthesis method of graphene oxide, characterization data, and other experimental protocols including supporting figures mentioned in the manuscript are given in the Supplementary Information, available at www.ias.ac.in/chemsci.

    These authors have contributed equally to the manuscript.

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    KURAPATI, R., REDDY, U.V., RAICHUR, A.M. et al. Facile synthesis of Graphene Oxide/Double-stranded DNA composite liquid crystals and Hydrogels. J Chem Sci 128, 325–330 (2016). https://doi.org/10.1007/s12039-016-1043-y

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    • DOI: https://doi.org/10.1007/s12039-016-1043-y

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