Synthesis and characterization of new thiourea and urea derivatives of 6-fluoro-3-(piperidin-4-yl)benzo[d] isoxazole: In vitro Antimicrobial and Antioxidant activity

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A new class of antimicrobial and antioxidant agents, based on thiourea and urea derivatives of 6-fluoro-3-(piperidin-4-yl)benzo[d] isoxazole were synthesized by adopting a simple and efficient method. Synthesized compounds were characterized by spectral data of IR, 1H, 13C NMR and mass spectra. The compounds were evaluated for their efficacy as antimicrobial and antioxidant agents. A few compounds showed good antibacterial, antifungal and antioxidant activity when compared to standard drugs and thus represent a new class of promising lead compounds.

A new series of thiourea and urea derivatives of 6-fluoro-3-(piperidin-4-yl)benzo[d] isoxazole were synthesized in a convenient way. The in vitro antimicrobial activity of the title compounds were screened against selected organisms by disc diffusion technique and the antioxidant activity were evaluated by H2O2 and DPPH Methods.

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The authors are thankful to Department of Science and Technology (DST) Innovation in Science pursuit for inspired research (INSPIRE), New Delhi for financial support.

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Correspondence to CHAMARTHI NAGA RAJU.

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Supplementary Information

Experimental details and tables of results of antibacterial, antifungal and antioxidant (DPPH and H 2 O 2 methods) activities, numbering of the title compound and scanned spectra of 1H and 13C of 8c and 9d compounds are given in the Supplementary Information which is available at

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SUDHAMANI, H., BASHA, S.T., VENKATESWARLU, N. et al. Synthesis and characterization of new thiourea and urea derivatives of 6-fluoro-3-(piperidin-4-yl)benzo[d] isoxazole: In vitro Antimicrobial and Antioxidant activity. J Chem Sci 127, 1739–1746 (2015).

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  • Isothiocyanates
  • Isocyanates
  • 6-Fluoro-3-(piperidin-4-yl)benzo[d] isoxazole
  • Antimicrobial and Antioxidant activity