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DIFLUORPHOS and SYNPHOS in asymmetric catalysis: Synthetic applications

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Abstract

Enantiomerically pure diphosphines play an important role in various homogeneous metalcatalyzed asymmetric reactions. Over the last few years, our group has been involved in the design and synthesis of atropisomeric ligands named SYNPHOS and DIFLUORPHOS with complementary stereoelectronic properties. This paper shows the high catalytic performances of DIFLUORPHOS, SYNPHOS and SYNPHOS analogues for some C–H and C–C bond forming processes as well as for the synthesis of biorelevant targets.

Enantiomerically pure diphosphines play an important role in various homogeneous metal-catalysed asymmetric reactions. This study shows the high catalytic performances of atropisomeric ligands DIFLUORPHOS, SYNPHOS and SYNPHOS analogues for some C–H and C–C bond-forming processes as well as for the synthesis of biorelevant targets.

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  1. Institut de Recherche de Chimie Paris, CNRS – Chimie ParisTech, 11 rue Pierre et Marie Curie, 75231, Paris Cedex 05, France

    SEBASTIEN PREVOST, TAHAR AYAD, JEAN-PIERRE GENET, PHANNARATH PHANSAVATH & VIRGINIE RATOVELOMANANA-VIDAL

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PREVOST, S., AYAD, T., GENET, JP. et al. DIFLUORPHOS and SYNPHOS in asymmetric catalysis: Synthetic applications. J Chem Sci 126, 325–340 (2014). https://doi.org/10.1007/s12039-014-0571-6

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