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Binding of reactive organophosphate by oximes via hydrogen bond

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Abstract

In this contribution, the ability of simple oximes to bind a well-known nerve agent simulant (dimethylmethylphosphonate, DMMP) via hydrogen bond is reported. UV/Vis measurements indicate the formation of 1:1 complexes. 1H-, 31P-NMR titrations and T-ROESY experiments confirm that oximes bind the organophosphate via hydrogen bond.

The ability of simple oximes to bind a well-known nerve agent simulant (dimethylmethylphosphonate, DMMP) via hydrogen bond is reported. UV/Vis measurements indicate the formation of 1:1 complexes. 1H-, 31P-NMR titrations and T-ROESY experiments give evidence that oximes bind the organophosphate via hydrogen bond.

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Acknowledgement

Authors thank Università di Catania for financial support.

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Authors and Affiliations

  1. Dipartimento di Scienze Chimiche, Università di Catania, viale A Doria 6, 95125, Catania, Italy

    ANDREA PAPPALARDO, MARIA E AMATO, FRANCESCO P BALLISTRERI, VALENTINA LA PAGLIA FRAGOLA, GAETANO A TOMASELLI, ROSA MARIA TOSCANO & GIUSEPPE TRUSSO SFRAZZETTO

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  1. ANDREA PAPPALARDO
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  2. MARIA E AMATO
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  3. FRANCESCO P BALLISTRERI
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  4. VALENTINA LA PAGLIA FRAGOLA
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  6. ROSA MARIA TOSCANO
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  7. GIUSEPPE TRUSSO SFRAZZETTO
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Correspondence to GIUSEPPE TRUSSO SFRAZZETTO.

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PAPPALARDO, A., AMATO, M.E., BALLISTRERI, F.P. et al. Binding of reactive organophosphate by oximes via hydrogen bond. J Chem Sci 125, 869–873 (2013). https://doi.org/10.1007/s12039-013-0463-1

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  • DOI: https://doi.org/10.1007/s12039-013-0463-1

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