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Synthesis and antimicrobial activities of new oxime carbamates of 3-aryl-2-thioquinazolin-4(3H)-one

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Abstract

S-alkylation of 3-aryl-2-thioquinazolin-4(3H)-one (1) with chloroacetone gave 2-(propanonyl thio)-3-arylquinazol-4(3H)ones (2). Further, the treatment of compound (2) with hydroxylamine hydrochloride gave the corresponding oximes (3) which on reaction with phenyl isocyanate in THF yielded corresponding oxime carbamates 4. The synthesized compounds have been confirmed using IR and 1H NMR, mass spectral data together with elemental analysis. All newly synthesized compounds have been tested for their antibacterial and antifungal activities.

Corresponding oxime carbamates (4) were synthesized by using 3-aryl-2-thioquinazolin-4(3H)-one (1) as starting material. This step-wise conversion involves S-alkylation of 3-aryl-2-thioquinazolin-4(3H)-one and oxime formation. The compounds have been tested for their antibacterial and antifungal activities.

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Correspondence to SURESH S PATIL.

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PATIL, S.S., JADHAV, S.D. & DESHMUKH, M.B. Synthesis and antimicrobial activities of new oxime carbamates of 3-aryl-2-thioquinazolin-4(3H)-one. J Chem Sci 124, 1043–1048 (2012). https://doi.org/10.1007/s12039-012-0302-9

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  • DOI: https://doi.org/10.1007/s12039-012-0302-9

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