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Journal of Chemical Sciences

, Volume 123, Issue 6, pp 937–942 | Cite as

Di(1H-benzo[d][1,2,3]triazol-1-yl)methane: An efficient ligand for copper and amine-free palladium-catalysed Sonogashira coupling reaction

  • JASPAL SINGH
  • AKHILESH KUMAR VERMAEmail author
Article

Abstract

An efficient Pd-catalysed Sonogashira coupling reaction was achieved in the absence of copper and amine with inorganic base using phosphene-free, air stable di(1H-benzo[d][1,2,3]triazol-1-yl)methane as ligand. The cross coupling of electron-rich, electron-defficient and hindered aryl halides with terminal alkynes afforded the internal alkynes in good to excellent yields.

Graphical Abstract

An efficient Pd-catalysed Sonogashira coupling reaction was achieved in the absence of copper and amine with inorganic base using phosphene-free, air stable di(1H-benzo[d][1,2,3]triazol-1-yl)methane as ligand. The cross coupling of electron-rich, electron-neutral, electron-defficient and hindered aryl halides with terminal alkynes afforded internal arylated alkynes in good to excellent yields.

Keywords

Palladium terminal alkynes benzotriazole amine-free copper-free 

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Supplementary material

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Copyright information

© Indian Academy of Sciences 2011

Authors and Affiliations

  1. 1.Synthetic Organic Chemistry Research Laboratory, Department of ChemistryUniversity of DelhiDelhiIndia

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