Abstract
This article describes recent developments in the design and implementation of various strategies towards the development of novel therapeutics using first principles from biology and chemistry. Strategies for multi-target therapeutics and network analysis with a focus on cancer and HIV are discussed. Methods for gene and siRNA delivery are presented along with challenges and opportunities for siRNA therapeutics. Advances in protein design methodology and screening are described, with a focus on their application to the design of antibody based therapeutics. Future advances in this area relevant to vaccine design are also mentioned.
Article PDF
Similar content being viewed by others
References
Russell R B and Aloy P 2008 Nat. Chem. Biol. 4 666
Zimmermann G R, Lehar J and Keith C T 2007 Drug Discov. Today 12 34
Hopkins A L 2008 Nat. Chem. Biol. 4 682
Whitehurst A W, Bodemann B O, Cardenas J, Ferguson D, Girard L, Peyton M, Minna J D, Michnoff C, Hao W, Roth M G, et al 2007 Nature 446 815
Engelman J A, Luo J and Cantley L C 2006 Nat. Rev. Genet. 7 606
Hennessy B T, Smith D L, Ram P T, Lu Y and Mills G B 2005 Nat. Rev. Drug. Discov. 4 988
Knight Z A, Gonzalez B, Feldman M E, Zunder E R, Goldenberg D D, Williams O, Loewith R, Stokoe D, Balla A, Toth B et al 2006 Cell 125 733
Barouch D H 2008 Nature 455 613
De Clercq E 2007 Nat. Rev. Drug Discov. 6 1001
Stier A and Sackmann E 1973 Biochim. Biophys. Acta. 311 400
Simons K and van Meer G 1988 Biochemistry 27 6197
Simons K and Toomre D 2000 Nat. Rev. Mol. Cell. Biol. 1 31
Carter G C, Bernstone L, Sangani D, Bee J W, Harder T and James W 2009 Virology 386 192
Garg R, Lodge R, Descoteaux A and Tremblay M J 2008 J. Infect. Dis. 197 1701
Miller A D 1998 Angew. Chem. Int. Ed. 37 1769
Bhattacharya S and Bajaj A 2005 Curr. Opin. Chem. Biol. 9 647
Bajaj A, Kondaiah P and Bhattacharya S 2008 Bioconjug. Chem. 19 1640
Bhattacharya S and De S 1999 Chemistry-A European J 5 2335
Bajaj A, Kondaiah P and Bhattacharya S 2007 Bioconjug. Chem. 18 1537
Bajaj A, Kondiah P and Bhattacharya S 2007 J. Med. Chem. 50 2432
Hannon G J and Rossi J J 2004 Nature 431 371
Fire A, Xu S, Montgomery M K, Kostas S A, Driver S E and Mello C C 1998 Nature 391 806
Preall J B, He Z, Gorra J M and Sontheimer E J 2006 Curr. Biol. 16 530
Gregory R I, Chendrimada T P, Cooch N and Shiekhattar R 2005 Cell 123 631
Ramachandran G N, Ramakrishnan C and Sasisekha an V 1963 J. Mol. Biol. 7 95
Ponder J W and Richards F M 1987 J. Mol. Biol. 193 775
Lasters I, De Maeyer M and Desmet J 1995 Protein Eng. 8 815
Kuhlman B and Baker D 2000 Proc. Natl. Acad. Sci. USA 97 10383
Hoogenboom H R 2005 Nat. Biotechnol. 23 1105
Lipinski C A, Lombardo F, Dominy B W and Feeney P J 2001 Adv. Drug. Deliv. Rev. 46 3
Aggarwal S 2007 Nat. Biotechnol. 25 1097
Milstein C 1980 Sci. Am. 243 66
Lonberg N 2008 Curr. Opin. Immunol. 20 450
Green L L, Hardy MC, Maynard-Currie C E, Tsuda H, Louie D M, Mendez M J, Abderrahim H, Noguchi M, Smith D H, Zeng Y et al 1994 Nat. Genet. 7 13
Lonberg N, Taylor L D, Harding F A, Trounstine M, Higgins K M, Schramm S R, Kuo C C, Mashayekh R, Wymore K, McCabe J G, et al 1994 Nature 368 856
Gibson T B, Ranganathan A and Grothey A 2006 Clin. Colorectal Cancer 6 29
Sidhu S S, Li B, Chen Y, Fellouse F A, Eigenbrot C and Fuh G 2004 J. Mol. Biol. 338 299
Fellouse F A, Wiesmann C and Sidhu S S 2004 Proc. Natl. Acad. Sci. USA 101 12467
Fellouse F A, Li B, Compaan D M, Peden A A, Hymowitz S G and Sidhu S S 2005 J. Mol. Biol. 348 1153
Lazar G A, Dang W, Karki S, Vafa O, Peng J S, Hyun L, Chan C, Chung H S, Eivazi A, Yoder S C, et al 2006 Proc. Natl. Acad. Sci. USA 103 4005
Olafsen T, Kenanova V E and Wu A M 2006 Nat. Protoc. 1 2048
Chiba Y and Jigami Y 2007 Curr. Opin. Chem. Biol. 11 670
Hamilton S R, Davidson R C, Sethuraman N, Nett J H, Jiang Y, Rios S, Bobrowicz P, Stadheim T A, Li H, Choi B K, et al 2006 Science 313 1441
Wildt S and Gerngross T U 2005 Nat. Rev. Microbiol. 3 119
Kowarik M, Numao S, Feldman M F, Schulz B L, Callewaert N, Kiermaier E, Catrein I and Aebi M 2006 Science 314 1148–1150
Luo X M, Maarschalk E, O’Connell R M, Wang P, Yang L and Baltimore D 2009 Blood 113 1422
Burton D R 2002 Nat. Rev. Immunol. 2 706
Author information
Authors and Affiliations
Corresponding author
Additional information
Reproduced from ‘Current Trends in Science’, Platinum Jubilee Special Publication, Indian Academy of Sciences, Bangalore, 2009. pp. 9–19.
Rights and permissions
About this article
Cite this article
Bhattacharya, S., Varadarajan, R. Emerging trends at the interface of chemistry and biology: Applications to the design of human therapeutics. J Chem Sci 122, 97–107 (2010). https://doi.org/10.1007/s12039-010-0034-7
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12039-010-0034-7