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Palladium-catalysed ortho arylation of acetanilides

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Abstract

The palladium-catalysed direct arylation of acetanilides by using C-H activation methodology has been demonstrated. Several acetanilides were coupled with aryl iodides in the presence of 10 mol% of Pd(OAc)2, 1·0 equiv of Cu(OTf)2, and 0·6 equiv of Ag2O to afford the corresponding products in moderate to excellent yields. The results showed that the amount of Ag2O was important for this protocol.

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Authors and Affiliations

  1. State Key Laboratory of Applied Organic Chemistry, Lanzhou, 73000, P.R. China

    Guo-Zhen Zhang, Cheng-Qun Chen, Xin-Hua Feng & Guo-Sheng Huang

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  1. Guo-Zhen Zhang
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  2. Cheng-Qun Chen
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  3. Xin-Hua Feng
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  4. Guo-Sheng Huang
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Correspondence to Guo-Sheng Huang.

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Zhang, GZ., Chen, CQ., Feng, XH. et al. Palladium-catalysed ortho arylation of acetanilides. J Chem Sci 122, 149–155 (2010). https://doi.org/10.1007/s12039-010-0016-9

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  • DOI: https://doi.org/10.1007/s12039-010-0016-9

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