Curcumin is a widely used therapeutic agent with a wide spectrum of biological and physiological applications like wound healing and interacts with the skin protein, collagen. This work reports the effect of curcumin on various physico-chemical properties of collagen. The results suggest that significant changes in viscosity and surface tension occur on collagen interacting with curcumin. Secondary structure analysis using circular dichroism shows that curcumin does not alter the triple helical structure of collagen. Increasing concentration of curcumin resulted in aggregation of the protein. Further, curcumin imparts high level of thermal stability to collagen with shrinkage temperature of collagen increasing from 60 to 90°C.
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Nishad Fathima, N., Saranya Devi, R., Rekha, K.B. et al. Collagen-curcumin interaction — A physico-chemical study. J Chem Sci 121, 509–514 (2009). https://doi.org/10.1007/s12039-009-0061-4
- circular dichroism (CD)
- differential scanning calorimetry (DSC)
- surface tension