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H2O2-HBr: A metal-free and organic solvent-free reagent system for the synthesis of arylaldehydes from methylarenes

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Abstract

A novel, practical and environmentally benign approach has been developed for the oxidation of methylarenes using H2O2-HBr system in water. Arylaldehydes containing electon-withdrawing groups are isolated in good to high yields. Methylarenes containing electon-donating groups, in contrast, are transformed into bromo-substituted arylaldehyde undergoing a tandem oxidation-bromination process.

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Authors and Affiliations

  1. Chemistry and Chemical Engineering Research Center of Iran, Pajoohesh Blvd., km 17, Karaj Hwy, Tehran, 14968-13151, Iran

    Mohammad Ghaffarzadeh, Mohammad Bolourtchian, Kourosh Tabar-Heydar, Iman Daryaei & Farshid Mohsenzadeh

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  1. Mohammad Ghaffarzadeh
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  2. Mohammad Bolourtchian
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  3. Kourosh Tabar-Heydar
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  4. Iman Daryaei
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  5. Farshid Mohsenzadeh
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Correspondence to Mohammad Ghaffarzadeh.

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Ghaffarzadeh, M., Bolourtchian, M., Tabar-Heydar, K. et al. H2O2-HBr: A metal-free and organic solvent-free reagent system for the synthesis of arylaldehydes from methylarenes. J Chem Sci 121, 177–182 (2009). https://doi.org/10.1007/s12039-009-0020-0

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  • DOI: https://doi.org/10.1007/s12039-009-0020-0

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