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Putative role of uncoupling proteins in mitochondria-nucleus communications and DNA damage response

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Abstract

Mitochondria-nucleus communications and DNA damage response (DDR) play roles in cellular stress and closely associate with a range of diseases. Mitochondrial uncoupling proteins (UCPs) are capable of uncoupling mitochondrial oxidative phosphorylation and protecting against oxidative stress. However, the potential role of UCPs in DDR and DDR-related mitochondria-nucleus communications remains unknown. The review deduces UCPs functions in mitochondria-nucleus communications implicated in metabolite regulation (e.g., reactive oxygen species) and Ca2+ signaling, and in DDR (e.g., base excision repair, double-strand DNA break repair, mitophagy and nuclear DNA degradation). Represented are shared microRNAs that regulate UCPs and DDR. It would provide novel insight into UCPs-mediated mitochondria-nucleus communications and DDR, and potentially promote drug target identification, drug discovery and clinical therapy of DDR-related diseases.

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Funding

This work was supported by the National Natural Science Foundation of China (Grant Numbers 31470716, 31000323 and 31070672) and the Natural Science Foundation of Jiangsu Province (Grant Number BK20131272).

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  1. State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Jiangsu, 210023, People’s Republic of China

    Yahan Niu, Chang Liu, Rui Zhang, Ying Jing & Donghai Li

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  1. Yahan Niu
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  2. Chang Liu
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  3. Rui Zhang
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Correspondence to Donghai Li.

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Corresponding editor: BJ Rao

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Niu, Y., Liu, C., Zhang, R. et al. Putative role of uncoupling proteins in mitochondria-nucleus communications and DNA damage response. J Biosci 46, 99 (2021). https://doi.org/10.1007/s12038-021-00224-9

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