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Is pseudoexfoliation glaucoma a neurodegenerative disorder?

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Abstract

Pseudoexfoliation (PEX) is a systemic age-related progressive disorder with ocular manifestations. The earlier stage of the disease, pseudoexfoliation syndrome (PEXS) involves deposition of white fibrillar aggregates on anterior and posterior eye tissues. It is also the cause of most common form of secondary glaucoma known as pseudoexfoliation glaucoma (PEXG). Studies in the past decade highlight the role of many genetic and environmental factors as the underlying cause of PEX pathogenesis. Latest research findings by various researchers and us present the view of PEX as a type of neurodegenerative disorder. Epidemiological studies have shown association of PEX with different forms of neurodegenerative diseases like Alzheimer’s, age-related macular degeneration and open angle glaucoma. Also, sharing of common genetic risk factors, abnormal protein aggregation and most importantly, progressive degeneration of neurons with age are some of the identifiable features seen in both PEX and other neurodegenerative diseases. In this review, we have compared the pathological symptoms and factors involved in the disease manifestation of PEXG with various forms of neurodegenerative disorders and categorized PEXG as a progressive neurodegenerative disorder.

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Acknowledgements

The authors thank their Clinical Collaborator, Dr. Pranjya P. Mohanty and Dr. Rohit Mendke for sharing the picture of a PEX affected eye. The authors also thank Ms. Ramani Shyam Kapuganti and Dr. Bushra Hayat for their feedback with editing. This work was supported by the institutional intramural grant to Debasmita P. Alone from Microbes and Disease Biology Project (Project No.: XII-R&D-NIS-5.04-02), National Institute of Science Education and Research, Department of Atomic Energy (India); and extramural research grant (Project No.: CRG/2019/002705) from Science and Engineering Research Board (India).

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  1. School of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, Khurda, 752 050, India

    Biswajit Padhy & Debasmita Pankaj Alone

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  1. Biswajit Padhy
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  2. Debasmita Pankaj Alone
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Correspondence to Debasmita Pankaj Alone.

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Communicated by Aurnab Ghose.

Corresponding editor: Aurnab Ghose

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Padhy, B., Alone, D.P. Is pseudoexfoliation glaucoma a neurodegenerative disorder?. J Biosci 46, 97 (2021). https://doi.org/10.1007/s12038-021-00217-8

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  • DOI: https://doi.org/10.1007/s12038-021-00217-8

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