Deconstructing age reprogramming
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It has been proposed that age reprogramming enables old cells to be rejuvenated without passage through an embryonic stage (Singh and Zacouto in J Biosci 35:315–319, 2010). As such, age reprogramming stands apart from the induced pluripotent stem (iPS) and nuclear transfer-embryonic stem (NT-ES) cell therapies where histo-compatible cells are produced only after passage through an embryonic stage. It avoids many of the disadvantages associated with iPS and NT-ES cell therapies. Experimental evidence in support of age reprogramming is burgeoning. Here, we discuss possible new approaches to enhance age reprogramming, which will have considerable benefits for regenerative therapies.
KeywordsAge reprogramming Epigenetic rejuvenation iPS cells reprogramming factors Epigenetic clock eAge
This work was supported by a grant from the Ministry of Education and Science of Russian Federation #14.Y26.31.0024 and Nazarbayev University (Grant No. 090118FD5311).