Skip to main content

Emerging roles of long non-coding RNAs in cancer

Abstract

Cancer is a physiological condition that has both the endogenous and exogenous influences on its progression. It originates from unusual cell growth, where the cells undergo massive genetic alterations, bypass the signaling machinery and compromise its genetic cohesion. Literature has well narrated the DNA damage studies including driver mutations that interfere with the treatment strategies. However, with evolving medical excellence, recent day studies are trying to unveil the contribution of RNAs in the progression of tumor malignancies. A number of non-coding RNAs have been identified as an active component in cancer genomics. This article aims to review the role of long non-coding RNAs in the spectra of cancers and its prognostic value as the biomarkers in molecular targeting with clinical utility and therapeutic beneficence.

This is a preview of subscription content, access via your institution.

Figure 1
Figure 2

References

  • Adams BD, Anastasiadou E, Esteller M, He L and Slack FJ 2015 The inescapable influence of noncoding RNAs in cancer. Cancer Res. 75 5206–5210

    CAS  PubMed  PubMed Central  Google Scholar 

  • Aird J, Baird AM, Lim MC, McDermott R, Finn SP and Gray SG 2018 Carcinogenesis in prostate cancer: the role of long non-coding RNAs. Non-coding RNA Res. 3 29–38

    CAS  Google Scholar 

  • Alves IT, Hiltemann S, Hartjes T, van der Spek P, Stubbs A, Trapman J and Jenster G 2013 Gene fusions by chromothripsis of chromosome 5q in the VCaP prostate cancer cell line. Hum. Genet. 132 709–713

    Google Scholar 

  • Anastasiadou E, Jacob LS and Slack FJ 2018 Non-coding RNA networks in cancer. Nat. Rev. Cancer 18 5

    CAS  PubMed  Google Scholar 

  • Balas MM and Johnson AM 2018 Exploring the mechanisms behind long noncoding RNAs and cancer. Non-coding RNA Res. (in press)

  • Bartonicek N, Maag JL and Dinger ME 2016 Long noncoding RNAs in cancer: mechanisms of action and technological advancements. Mol. Cancer 15 43

    PubMed  PubMed Central  Google Scholar 

  • Beckedorff FC, Amaral MS, Deocesano-Pereira C and Verjovski-Almeida S 2013 Long non-coding RNAs and their implications in cancer epigenetics. Biosci. Rep. 33 e00061

    PubMed  PubMed Central  Google Scholar 

  • Berger MF, Lawrence MS, Demichelis F, Drier Y, Cibulskis K, Sivachenko AY, Sboner A, Esgueva R, et al. 2011 The genomic complexity of primary human prostate cancer. Nature 470 214

    CAS  PubMed  PubMed Central  Google Scholar 

  • Bertrand C 2014 Long non-coding RNAs in cancer: the role of HOTAIR in epithelial-to-mesenchymal transition, PhD thesis, Université Pierre et Marie Curie-Paris VI

  • Bhan A and Mandal SS 2016 Estradiol-Induced Transcriptional Regulation of Long Non-Coding RNA, HOTAIR; in Estrogen Receptors. Methods in Molecular Biology (ed) KM Eyster (Humana Press, New York, NY) vol 1366

  • Bhan A, Hussain I, Ansari KI, Kasiri S, Bashyal A and Mandal SS 2013 Antisense transcript long noncoding RNA (lncRNA) HOTAIR is transcriptionally induced by estradiol. J Mol. Biol. 425 3707–3722

    CAS  PubMed  PubMed Central  Google Scholar 

  • Bhat SA, Ahmad SM, Mumtaz PT, Malik AA, Dar MA, Urwat U, Shah RA and Ganai NA 2016 Long non-coding RNAs: mechanism of action and functional utility. Non-coding RNA Res. 1 43–50

    Google Scholar 

  • Bijnsdorp IV, van Royen ME, Verhaegh GW and Martens-Uzunova ES 2017 The non-coding transcriptome of prostate cancer: implications for clinical practice. Mol. Diagn. Ther. 21 1–16

    Google Scholar 

  • Cai Q, Wang Z, Wang S, Weng M, Zhou D, Li C, Wang J, Chen E, et al. 2017 Long non-coding RNA LINC00152 promotes gallbladder cancer metastasis and epithelial–mesenchymal transition by regulating HIF-1α via miR-138. Open Biol. 7 160247

    PubMed  PubMed Central  Google Scholar 

  • Caslini C, Connelly JA, Serna A, Broccoli D and Hess JL 2009 MLL associates with telomeres and regulates telomeric repeat-containing RNA transcription. Mol. Cell Biol. 29 4519–4526

    CAS  PubMed  PubMed Central  Google Scholar 

  • Cerk S, Schwarzenbacher D, Adiprasito JB, Stotz M, Hutterer GC, Gerger A, Ling H, Calin GA, et al. 2016 Current status of long non-coding RNAs in human breast cancer. Int. J. Mol. Sci. 17 1485

    PubMed Central  Google Scholar 

  • Chatterjee M, Chinder P, Mannan AU, Sheela ML, Mukherjee U, Choudhury S, Lo C, Singh S et al. 2016 Genotype-phenotype analysis in an indian Family affected with Li-Fraumeni syndrome-role of genetic counselling. Int. J. Hum. Genet. 16 98–106

    Google Scholar 

  • Chatterjee M, Sheela ML, Mukherjee U, Patil S, Satheesh CT, Murugan K, Naik R, Rao N et al. 2016 Incidental findings in male breast carcinoma: a genetic counseling approach. Int. J. Hum. Genet. 16 120–127

    Google Scholar 

  • Chen B, Yu M, Chang Q, Lu Y, Thakur C, Ma D, Yi Z and Chen F 2013 Mdig de-represses H19 large intergenic non-coding RNA (lincRNA) by down-regulating H3K9me3 and heterochromatin. Oncotarget 4 1427

    PubMed  PubMed Central  Google Scholar 

  • Chen D, Sun Q, Cheng X, Zhang L, Song W, Zhou D, Lin J and Wang W 2016 Genome‐wide analysis of long noncoding RNA (lncRNA) expression in colorectal cancer tissues from patients with liver metastasis. Cancer Med. 5 1629–1639

    CAS  PubMed  PubMed Central  Google Scholar 

  • Chen J, Liu S and Hu X 2018 Long non-coding RNAs: crucial regulators of gastrointestinal cancer cell proliferation. Cell Death Dis. 4 50

    Google Scholar 

  • Cheng Z and Mao H 2017 Long Non-Coding RNA in Non-Small Cell Lung Cancers; in A Global Scientific Vision-Prevention, Diagnosis, and Treatment of Lung Cancer (ed) Marta Adonis InTech. https://doi.org/10.5772/66487

  • Collette J, Le Bourhis X and Adriaenssens E 2017 Regulation of human breast Cancer by the long non-coding RNA H19. Int. J. Mol. Sci. 18 2319

    PubMed Central  Google Scholar 

  • Deng, R, Liu B, Wang Y, Yan F, Hu S, Wang H, Wang T, Li B et al. 2016 High expression of the newly found long noncoding RNA Z38 promotes cell proliferation and oncogenic activity in breast cancer. J. Cancer 7 576

    CAS  PubMed  PubMed Central  Google Scholar 

  • Fan Y, Shen B, Tan M, Mu X, Qin Y, Zhang F and Liu Y 2014 Long non‐coding RNA UCA1 increases chemoresistance of bladder cancer cells by regulating Wnt signaling. FEBS J. 281 1750–1758

    CAS  PubMed  Google Scholar 

  • Fang TT, Sun XJ, Chen J, Zhao Y, Sun RX, Ren N and Liu BB 2014. Long non-coding RNAs are differentially expressed in hepatocellular carcinoma cell lines with differing metastatic potential. Asia. Pac. J. Cancer Prev. 15 10513–10524

    Google Scholar 

  • Feng L, Wang R, Lian M, Ma H, He N, Liu H, Wang H and Fang J 2016 Integrated analysis of long noncoding RNA and mRNA expression profile in advanced laryngeal squamous cell carcinoma. PLoS ONE 11 e0169232

    PubMed  PubMed Central  Google Scholar 

  • Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM 2010 Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int. J. Cancer 127 2893–2917

    CAS  PubMed  Google Scholar 

  • Fitzmaurice C, Dicker D, Pain A, Hamavid H, Moradi-Lakeh M, MacIntyre MF, Allen C, Hansen G et al. 2015 The global burden of cancer 2013. JAMA Oncol. 1 505–527

    PubMed  Google Scholar 

  • Glover AR, Zhao JT, Ip JC, Lee JC, Robinson BG, Gill AJ, Soon PSH and Sidhu SB 2015 Long noncoding RNA profiles of adrenocortical cancer can be used to predict recurrence. Endocr.-Relat. Cancer. 22 99–109

    CAS  PubMed  Google Scholar 

  • Goenka A, Sengupta S, Pandey R, Parihar R, Mohanta GC, Mukerji M and Ganesh S 2016 Human satellite-III non-coding RNAs modulate heat-shock-induced transcriptional repression. J. Cell Sci. 129 3541–3552

    CAS  PubMed  Google Scholar 

  • Holliday DL and Speirs V 2011 Choosing the right cell line for breast cancer research. Breast Cancer Res. 13 215

    PubMed  PubMed Central  Google Scholar 

  • Hong S, Kim T, Sung KB, Kim P, Ha H, Kim A and Lee MG 2003 Extrahepatic spread of hepatocellular carcinoma: a pictorial review. Eur. Rradiol. 13 874–882

    Google Scholar 

  • Hu X, Bao J, Wang Z, Zhang Z, Gu P, Tao F, Cui D and Jiang W 2016 The plasma lncRNA acting as fingerprint in non-small-cell lung cancer. Tumor Biol. 37 3497–3504

    CAS  Google Scholar 

  • Huarte M, Guttman M, Feldser D, Garber M, Koziol MJ, Kenzelmann-Broz D, Khalil AM, Zuk O et al. 2010. A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell 142 409–419

    CAS  PubMed  PubMed Central  Google Scholar 

  • Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D 2011 Global cancer statistics. CA Cancer J. Clin. 61 69–90

    PubMed  Google Scholar 

  • Ji TT, Huang X, Jin J, Pan SH and Zhuge XJ 2016 Inhibition of long non-coding RNA TUG1 on gastric cancer cell transference and invasion through regulating and controlling the expression of miR-144/c-Met axis. Asia. Pac. J. Trop. Med. 9 508–512

    CAS  Google Scholar 

  • Jiang HJ, Wang S and Ding Y 2014 Emerging paradigms of long non-coding RNAs in gastrointestinal cancer. Am. J. Stem Cells. 3 63

    CAS  PubMed  PubMed Central  Google Scholar 

  • Kaplan R, Luettich K, Heguy A, Hackett NR, Harvey BG and Crystal RG 2003 Monoallelic up-regulation of the imprinted H19 gene in airway epithelium of phenotypically normal cigarette smokers. Cancer Res. 63 1475–1482

    CAS  PubMed  Google Scholar 

  • Ke K, Sun Z and Wang Z 2018 Downregulation of long non-coding RNA GAS5 promotes cell proliferation, migration and invasion in esophageal squamous cell carcinoma. Oncol. Lett. 16 1801–1808

    PubMed  PubMed Central  Google Scholar 

  • Leygue E, Dotzlaw H, Watson PH and Murphy LC 1999 Expression of the steroid receptor RNA activator in human breast tumors. Cancer Res. 59 4190–4193

    CAS  PubMed  Google Scholar 

  • Li C, Yang L and Lin C 2014 Long noncoding RNAs in prostate cancer: mechanisms and applications. Mol. Cell. Oncol. 1 e963469

    PubMed  PubMed Central  Google Scholar 

  • Li SQ, Li F, Xiao Y, Wang CM, Tuo L, Hu J, Yang XB, Wang JS, et al. 2014 Comparison of long non-coding RNAs, microRNAs and messenger RNAs involved in initiation and progression of esophageal squamous cell carcinoma. Mol. Med. Rep. 10 652–662

    CAS  PubMed  PubMed Central  Google Scholar 

  • Li J, Wang Y, Yu J, Dong R and Qiu H 2015 A high level of circulating HOTAIR is associated with progression and poor prognosis of cervical cancer. Tumor Biol. 36 1661–1665

    CAS  Google Scholar 

  • Li W, Zhai L, Wang H, Liu C, Zhang J, Chen W and Wei Q 2016 Downregulation of LncRNA GAS5 causes trastuzumab resistance in breast cancer. Oncotarget. 7 27778

    PubMed  PubMed Central  Google Scholar 

  • Li J, Liu Y, Li P, Guo Y, Liu Y and Ren Y 2017 Long noncoding RNA CCAT2 promotes proliferation and metastasis in non-small cell lung cancer through the Wnt pathway. Int. J. Clin. Exp. Pathol. 10 7983–7990

    PubMed  PubMed Central  Google Scholar 

  • Lin CP and He L 2017 Noncoding RNAs in cancer development. Annu. Rev. Cancer Biol. 1 163–84

    Google Scholar 

  • Liu XH, Liu ZL, Sun M, Liu J, Wang ZX and De W 2013 The long non-coding RNA HOTAIR indicates a poor prognosis and promotes metastasis in non-small cell lung cancer. BMC Cancer 13 464

    PubMed  PubMed Central  Google Scholar 

  • Liu Z, Sun M, Lu K, Liu J, Zhang M, Wu W, De W, Wang Z et al. 2013 The long noncoding RNA HOTAIR contributes to cisplatin resistance of human lung adenocarcinoma cells via downregualtion of p21WAF1/CIP1 expression. PLoS ONE 8 e77293

    CAS  PubMed  PubMed Central  Google Scholar 

  • Llovet JM, Lencioni R, Gaile PR et al. 2012 EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol. 56 908–43

    Google Scholar 

  • Luo X, Qiu Y, Jiang Y, Chen F, Jiang L, Zhou Y, Dan H, Zeng X et al. 2018 Long non-coding RNA implicated in the invasion and metastasis of head and neck cancer: possible function and mechanisms. Mol. Cancer 17 14

    PubMed  PubMed Central  Google Scholar 

  • Lv M, Xu P, Wu Y, Huang L, Li W, Lv S, Wu X, Zeng X, et al. 2016 LncRNAs as new biomarkers to differentiate triple negative breast cancer from non-triple negative breast cancer. Oncotarget. 7 13047

    PubMed  PubMed Central  Google Scholar 

  • Ma Y, Yang Y, Wang F, Moyer MP, Wei Q, Zhang P, Yang Z, Liu W, et al. 2016 Long non-coding RNA CCAL regulates colorectal cancer progression by activating Wnt/β-catenin signaling pathway via suppression of activator protein 2α. Gut 65 1494–1504

    CAS  PubMed  Google Scholar 

  • Malik B and Feng FY 2016 Long noncoding RNAs in prostate cancer: overview and clinical implications. Asia. J. Androl. 18 568

    CAS  Google Scholar 

  • Martens-Uzunova ES, Böttcher R, Croce CM, Jenster G, Visakorpi T and Calin GA 2014 Long noncoding RNA in prostate, bladder, and kidney cancer. Eur. Urol. 65 1140–1151

    CAS  PubMed  Google Scholar 

  • Matouk IJ, Mezan S, Mizrahi A, Ohana P, Abu-lail R, Fellig Y, Galun E and Hochberg A 2010 The oncofetal H19 RNA connection: hypoxia, p53 and cancer. Biochim. Biophys. Acta (BBA)-Mol. Cell Res. 1803 443–451

    CAS  Google Scholar 

  • Mitra R, Chen X, Greenawalt EJ, Maulik U, Jiang W, Zhao Z and Eischen CM 2017 Decoding critical long non-coding RNA in ovarian cancer epithelial-to-mesenchymal transition. Nat. Commun. 8 1604

    PubMed  PubMed Central  Google Scholar 

  • Ong MS, Cai W, Tan TZ, Huang RYJ, Hooi SC, Yap CT and Kumar AP 2018 Long non-coding RNA landscape in colorectal cancer. RNA Dis. 5 e1628

    Google Scholar 

  • Palazzo AF and Lee ES 2015 Non-coding RNA: what is functional and what is junk? Front. Genet. 6 2

    PubMed  PubMed Central  Google Scholar 

  • Paralkar VR and Weiss MJ 2013 Long noncoding RNAs in biology and hematopoiesis. Blood 121 4842–4846

    CAS  PubMed  PubMed Central  Google Scholar 

  • Park SM, Park SJ, Kim HJ, Kwon OH, Kang TW, Sohn HA, Kim SK, Noh SM et al. 2013 A known expressed sequence tag, BM742401, is a potent lincRNA inhibiting cancer metastasis. Exp. Mol. Med. 45 e31

    PubMed  PubMed Central  Google Scholar 

  • Peng WX, Koirala P and Mo YY 2017 LncRNA-mediated regulation of cell signaling in cancer. Oncogene 36 5661-5667

    CAS  PubMed  PubMed Central  Google Scholar 

  • Peter S, Borkowska E, Drayton RM, Rakhit CP, Noon AP, Chen W and Catto JW 2014 Identification of differentially expressed long non-coding RNAs in bladder cancer. Clin. Cancer. Res. 20 5311–5321

    CAS  PubMed  Google Scholar 

  • Poliseno L, Salmena L, Zhang J, Carver B, Haveman WJ and Pandolfi PP 2010 A coding-independent function of gene and pseudogene mRNAs regulates tumor biology. Nature 465 1033

    CAS  PubMed  PubMed Central  Google Scholar 

  • Pop-Bica C, Gulei D, Cojocneanu-Petric R, Braicu C, Petrut B and Berindan-Neagoe I 2017 Understanding the role of non-coding rnas in bladder cancer: From dark matter to valuable therapeutic targets. Int. J. Mol. Sci. 18 1514

    PubMed Central  Google Scholar 

  • Prensner JR, Iyer MK, Balbin OA, Dhanasekaran SM, Cao Q, Brenner JC, Laxman B, Asangani IA, et al. 2011 Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression. Nat. Biotechnol. 29 742–749

    CAS  PubMed  PubMed Central  Google Scholar 

  • Prensner JR, Zhao S, Erho N, Schipper M, Iyer MK, Dhanasekaran SM, Magi-Galluzzi C, Mehra R et al. 2014 RNA biomarkers associated with metastatic progression in prostate cancer: a multi-institutional high-throughput analysis of SChLAP1. Lancet Oncol. 15 1469–1480.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Qi P and Du X 2013 The long non-coding RNAs, a new cancer diagnostic and therapeutic gold mine. Mod. Pathol. 26 155–165

    CAS  PubMed  Google Scholar 

  • Qi P, Zhou XY and Du X 2016 Circulating long non-coding RNAs in cancer: current status and future perspectives. Mol. Cancer. 15 39

    PubMed  PubMed Central  Google Scholar 

  • Rangel LB, Sherman-Baust CA, Wernyj RP, Schwartz DR, Cho KR and Morin PJ 2003 Characterization of novel human ovarian cancer-specific transcripts (HOSTs) identified by serial analysis of gene expression. Oncogene 22 7225

    CAS  PubMed  Google Scholar 

  • Redis RS, Sieuwerts AM, Look MP, Tudoran O, Ivan C, Spizzo R, Zhang X, de Weerd V et al. 2013 CCAT2, a novel long non-coding RNA in breast cancer: expression study and clinical correlations. Oncotarget 4 1748

    PubMed  PubMed Central  Google Scholar 

  • Ren S, Liu Y, Xu W, Sun Y, Lu J, Wang F, Wei M, Shen J et al. 2013 Long noncoding RNA MALAT-1 is a new potential therapeutic target for castration resistant prostate cancer. J. Urol. 190 2278–2287

    CAS  PubMed  Google Scholar 

  • Sahu A, Singhal U and Chinnaiyan AM 2015 Long noncoding RNAs in cancer: from function to translation. Trends Cancer 1 93–109

    PubMed  PubMed Central  Google Scholar 

  • Sampl S, Pramhas S, Stern C, Preusser M, Marosi C and Holzmann K 2012 Expression of telomeres in astrocytoma WHO grade 2 to 4: TERRA level correlates with telomere length, telomerase activity, and advanced clinical grade. Transl. Oncol. 5 56IN1–65IN4

    PubMed  PubMed Central  Google Scholar 

  • Sengupta S, Parihar R and Ganesh S 2009 Satellite III non-coding RNAs show distinct and stress-specific patterns of induction. Biochem. Biophys. Res. Commun. 382 102–107

    CAS  PubMed  Google Scholar 

  • Shen MM 2013 Chromoplexy: a new category of complex rearrangements in the cancer genome. Cancer Cell 23 567–569

    CAS  PubMed  PubMed Central  Google Scholar 

  • Shen X, Xie B, Ma Z, Yu W, Wang W, Xu D, Yan X, Chen B et al. 2015 Identification of novel long non-coding RNAs in triple-negative breast cancer. Oncotarget 6 21730

    PubMed  PubMed Central  Google Scholar 

  • Song H, Sun W, Ye G, Ding X, Liu Z, Zhang S, Xia T, Xiao B et al. 2013 Long non-coding RNA expression profile in human gastric cancer and its clinical significances. J. Transl. Med. 11 225

    PubMed  PubMed Central  Google Scholar 

  • Song W, Sun Y, Lin J and Bi X 2018 Current research on head and neck cancer-associated long noncoding RNAs. Oncotarget 9 1403

    PubMed  Google Scholar 

  • Soudyab M, Iranpour M and Ghafouri-Fard S 2016 The role of long non-coding RNAs in breast cancer. Arch. Iran. Med. (AIM) 19 508–517

    Google Scholar 

  • Stewart BWKP and Wild CP 2017 World cancer report 2014. Health

  • Su X, Li G and Liu W 2017 The long noncoding RNA cancer susceptibility candidate 9 promotes nasopharyngeal carcinogenesis via stabilizing HIF1α. DNA Cell. Biol. 36 394–400

    CAS  PubMed  Google Scholar 

  • Su F, He W, Chen C, Liu M, Liu H, Xue F, Bi J, Xu D et al. 2018 The long non-coding RNA FOXD2-AS1 promotes bladder cancer progression and recurrence through a positive feedback loop with Akt and E2F1. Cell Death Dis. 9 233

    PubMed  PubMed Central  Google Scholar 

  • Sun W, Wu Y, Yu X, Liu Y, Song H, Xia T, Xiao B and Guo J 2013 Decreased expression of long noncoding RNA AC096655. 1–002 in gastric cancer and its clinical significance. Tumor Biol. 34 2697–2701

    CAS  Google Scholar 

  • Tang J, Jiang R, Deng L, Zhang X, Wang K, Sun B 2015 Circulation long non-coding RNAs act as biomarkers for predicting tumorigenesis and metastasis in hepatocellular carcinoma. Oncotarget 6 4505

    PubMed  PubMed Central  Google Scholar 

  • Tong YS, Wang XW, Zhou XL, Liu ZH, Yang TX, Shi WH, Xie HW, Lv J et al. 2015 Identification of the long non-coding RNA POU3F3 in plasma as a novel biomarker for diagnosis of esophageal squamous cell carcinoma. Mol. Cancer. 14 3

    PubMed  PubMed Central  Google Scholar 

  • Tripathi V, Ellis JD, Shen Z, Song DY, Pan Q, Watt AT, Freier SM, Bennett CF et al. 2010 The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation. Mol. Cell. 39 925–938

    CAS  PubMed  PubMed Central  Google Scholar 

  • Tsai KW, Lo YH, Liu H, Yeh CY, Chen YZ, Hsu CW, Chen WS. and Wang JH 2018 Linc00659, a long noncoding RNA, acts as novel oncogene in regulating cancer cell growth in colorectal cancer. Mol. Cancer 17 72

    PubMed  PubMed Central  Google Scholar 

  • Tuncer HB and Bensan AE 2014 Noncoding RNAs and cancer. Turk. J. Biol. 38 817–28

    Google Scholar 

  • Van Grembergen O, Bizet M, Eric J, Calonne E, Putmans P, Brohée S, Olsen C, Guo M et al. 2016 Portraying breast cancers with long noncoding RNAs. Sci. Adv. 2 e1600220

    PubMed  PubMed Central  Google Scholar 

  • Wang KC and Chang HY 2011 Molecular mechanisms of long noncoding RNAs. Mol. Cell. 43 904–914

    CAS  PubMed  PubMed Central  Google Scholar 

  • Wang Y, Zhang D, Wu K, Zhao Q, Nie Y and Fan D 2014 Long noncoding RNA MRUL promotes ABCB1 expression in multidrug-resistant gastric cancer cell sublines. Mol. Cell. Biol. 34 3182–3193

    PubMed  PubMed Central  Google Scholar 

  • Wu W, Wagner EK, Hao Y, Rao X, Dai H, Han J, Chen J, Storniolo AMV et al. 2016 Tissue-specific co-expression of long non-coding and coding RNAs Associated with breast cancer. Sci. Rep. 6 32731

    CAS  PubMed  PubMed Central  Google Scholar 

  • Xu ZY, Yu QM, Du YA, Yang LT, Dong RZ, Huang L, Yu PF and Cheng XD 2013 Knockdown of long non-coding RNA HOTAIR suppresses tumor invasion and reverses epithelial-mesenchymal transition in gastric cancer. Int. J. Biol. Sci. 9 587

    PubMed  PubMed Central  Google Scholar 

  • Xu S, Sui S, Zhang J, Bai N, Shi Q, Zhang G, Gao S, You Z, et al. 2015 Downregulation of long noncoding RNA MALAT1 induces epithelial-to-mesenchymal transition via the PI3K-AKT pathway in breast cancer. Int. J. Clin. Exp. Pathol. 8 4881

    CAS  PubMed  PubMed Central  Google Scholar 

  • Xu T, Lin CM, Cheng SQ, Min J, Li L, Meng XM, Huang C, Zhang L et al. 2018 Pathological bases and clinical impact of long noncoding RNAs in prostate cancer: a new budding star. Mol. Cancer 17 103

    PubMed  PubMed Central  Google Scholar 

  • Yang F, Bi J, Xue X, Zheng L, Zhi K, Hua J and Fang G 2012 Up‐regulated long non‐coding RNA H19 contributes to proliferation of gastric cancer cells. FEBS J. 279 3159–3165

    CAS  PubMed  Google Scholar 

  • Yang F, Lyu S, Dong S, Liu Y, Zhang X and Wang O 2016 Expression profile analysis of long noncoding RNA in HER-2-enriched subtype breast cancer by next-generation sequencing and bioinformatics. Onco Targets Ther. 9 761

    CAS  PubMed  PubMed Central  Google Scholar 

  • Yang X, Duan B and Zhou X 2017 Long non-coding RNA FOXD2-AS1 functions as a tumor promoter in colorectal cancer by regulating EMT and Notch signaling pathway. Eur. Rev. Med. Pharmacol. Sci. 21 3586–3591

    CAS  PubMed  Google Scholar 

  • Yang Y, Junjie P, Sanjun C and Ma Y 2017 Long non-coding RNAs in colorectal cancer: progression and future directions. J. Cancer 8 3212

    PubMed  PubMed Central  Google Scholar 

  • Zhan L, Li J and Wei B 2018 Long non-coding RNAs in ovarian cancer. J. Exp. Clin. Cancer Res. 37 120

    PubMed  PubMed Central  Google Scholar 

  • Zhang X, Rice K, Wang Y, Chen W, Zhong Y, Nakayama Y, Zhou Y and Klibanski A 2009 Maternally expressed gene 3 (MEG3) noncoding ribonucleic acid: isoform structure, expression, and functions. Endocrinol. 151 939–947

    Google Scholar 

  • Zhang K, Luo Z, Zhang Y, Song X, Zhang L, Wu L and Liu J 2017 Long non-coding RNAs as novel biomarkers for breast cancer invasion and metastasis. Oncol. Lett. 14 1895–1904

    CAS  PubMed  PubMed Central  Google Scholar 

  • Zhao J, Liu Y, Zhang W, Zhou Z, Wu J, Cui P, Zhang Y and Huang G 2015 Long non-coding RNA Linc00152 is involved in cell cycle arrest, apoptosis, epithelial to mesenchymal transition, cell migration and invasion in gastric cancer. Cell Cycle 14 3112–3123

    CAS  PubMed  PubMed Central  Google Scholar 

  • Zhong Y, Gao D, He S, Shuai C and Peng S 2016 Dysregulated expression of long noncoding RNAs in ovarian cancer. Int. J. Gynecol. Cancer. 26 1564

    PubMed  PubMed Central  Google Scholar 

  • Zhou Y, Wang C, Liu X, Wu C and Yin H 2017 Long non-coding RNA HOTAIR enhances radioresistance in MDA-MB231 breast cancer cells. Oncol. Lett. 13 1143–1148

    CAS  PubMed  PubMed Central  Google Scholar 

  • Zhu Q, Hoong N, Aslanian A, Hara T, Benner C, Heinz S, Miga KH, Ke E, Verma S, Soroczynski J and Yates JR 2018 Heterochromatin-encoded satellite RNAs induce breast cancer. Mol. Cell. 70 842–853

    CAS  PubMed  PubMed Central  Google Scholar 

  • Zou AE, Ku J, Honda TK, Yu V, Kuo SZ, Zheng H, Xuan Y, Saad MA et al. 2015 Transcriptome sequencing uncovers novel long noncoding and small nucleolar RNAs dysregulated in head and neck squamous cell carcinoma. RNA 21 1122–1134

    CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Sonali Sengupta.

Additional information

Communicated by Ullas Kolthur-Seetharam.

Corresponding editor: Ullas Kolthur-Seetharam

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Chatterjee, M., Sengupta, S. Emerging roles of long non-coding RNAs in cancer. J Biosci 44, 22 (2019). https://doi.org/10.1007/s12038-018-9820-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s12038-018-9820-z

Keywords

  • Biomarkers
  • cancers
  • DNA damages
  • genetic assaults
  • long non-coding RNAs
  • therapeutics