Journal of Biosciences

, Volume 42, Issue 2, pp 333–344 | Cite as

Regulation of dynamin family proteins by post-translational modifications

  • Usha P Kar
  • Himani Dey
  • Abdur RahamanEmail author


Dynamin superfamily proteins comprising classical dynamins and related proteins are membrane remodelling agents involved in several biological processes such as endocytosis, maintenance of organelle morphology and viral resistance. These large GTPases couple GTP hydrolysis with membrane alterations such as fission, fusion or tubulation by undergoing repeated cycles of self-assembly/disassembly. The functions of these proteins are regulated by various post-translational modifications that affect their GTPase activity, multimerization or membrane association. Recently, several reports have demonstrated variety of such modifications providing a better understanding of the mechanisms by which dynamin proteins influence cellular responses to physiological and environmental cues. In this review, we discuss major post-translational modifications along with their roles in the mechanism of dynamin functions and implications in various cellular processes.


Dynamin endocytosis GTPase mitochondrial dynamics post-translational modification 

Abbreviations used


calmodulin-dependent protein kinase 1alpha




cyclin-dependent kinase


dynamin-related protein


endothellial nitric oxide synthase


endoplasmic reticulum


extracellular regulated kinase


GTPase effector domain


guanosine triphosphate


histone deacetylase


Janus kinase


mitochondria-associated ER membrane


middle domain




nitric oxide


nitric oxide synthase


outer mitochondrial membrane


Pleckstrin homology domain


protein kinase A


protein kinase C


proline-rich domain


reactive oxygen species


Src homology 3





The work in the laboratory is supported by DBT grant (BT/PR14643/BRB/10/862/2010).


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© Indian Academy of Sciences 2017

Authors and Affiliations

  1. 1.School of Biological SciencesNational Institute of Science Education and Research-Bhubaneswar, HBNIOdishaIndia

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