Diverse roles of WDR5-RbBP5-ASH2L-DPY30 (WRAD) complex in the functions of the SET1 histone methyltransferase family
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WD repeat containing protein 5 (WDR5), Retinoblastoma Binding Protein 5 (RbBP5), Absent-Small-Homeotic-2-Like protein (ASH2L), and Dumpy-30 (Dpy30) have been reported to be the integral and shared components of all the SET1 family of histone 3 lysine 4 histone methyltransferase (HMT) complexes. Collectively called the WRAD complex, these proteins are pivotal to the HMT activity of the SET1 complexes. Recent reports highlight the novel non-canonical functions of WRAD in cellular processes other than its well-studied role in histone methylation and gene expression. In this review, we examine the diversity in emerging transcription-independent functions of WRAD.
KeywordsCell cycle regulation SET1 family transcription WRAD
We thank members of the Laboratory of Cell Cycle Regulation for valuable feedback. AA is the recipient of Junior and Senior Research Fellowships of the Council of Scientific and Industrial Research (CSIR), India, towards the pursuit of a Ph.D. degree of Manipal University. This work was supported in part by a grant from DBT (to ST; BT/BR15453/BRB/10/927/2011), DST (to ST; SB/SO/BB-069/2013) and CDFD core funds.
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