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Insights into eisosome assembly and organization

Journal of Biosciences volume 37, pages 295–300 (2012)Cite this article

Abstract

Eisosomes, large protein complexes that are predominantly composed of BAR-domain-containing proteins Pil1 and its homologs, are situated under the plasma membrane of ascomycetes. A successful targeting of Pil1 onto the future site of eisosome accompanies maturation of eisosome. During or after recruitment, Pil1 undergoes self-assembly into filaments that can serve as scaffolds to induce membrane furrows or invaginations. Although a consequence of the invagination is likely to redistribute particular proteins and lipids to a different location, the precise physiological role of membrane invagination and eisosome assembly awaits further investigation. The present review summarizes recent research findings within the field regarding the detailed structural and functional significance of Pil1 on eisosome organization.

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Authors and Affiliations

  1. Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL, 60637, USA

    E. R. Murphy

  2. Department of Biology, Missouri State University, Springfield, MO, 65897, USA

    K. T. Kim

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  1. E. R. Murphy
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  2. K. T. Kim
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Correspondence to K. T. Kim.

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Corresponding editor: Luis M Corrochano

[Murphy ER and Kim KT 2012 Insights into eisosome assembly and organization. J. Biosci. 37 1–6] DOI 10.1007/s12038-012-9206-6

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Murphy, E.R., Kim, K.T. Insights into eisosome assembly and organization. J Biosci 37, 295–300 (2012). https://doi.org/10.1007/s12038-012-9206-6

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  • DOI: https://doi.org/10.1007/s12038-012-9206-6

Keywords

  • Eisosome
  • membrane organization
  • Pil1