Journal of Biosciences

, Volume 36, Issue 1, pp 5–11 | Cite as

Tone up your chromatin and stay young

  • Navneet K Matharu
  • Rakesh K MishraEmail author




Aging chromatin epigenetics histones 



NKM acknowledges CSIR for financial support. RKM acknowledges research grants from HFSP, CEFIPPRA and DBT, Government of India.


  1. Bantignies F and Cavalli G 2006 Cellular memory and dynamic regulation of polycomb group proteins. Curr. Opin. Cell Biol. 18 275–283PubMedCrossRefGoogle Scholar
  2. Bhalla N, Biggins S and Murray AW 2002 Mutation of YCS4, a budding yeast condensin subunit, affects mitotic and nonmitotic chromosome behavior. Mol. Biol. Cell 13 632–645PubMedCrossRefGoogle Scholar
  3. Blander G and Guarente L 2004 The Sir2 family of protein deacetylases. Annu. Rev. Biochem. 73 417–435PubMedCrossRefGoogle Scholar
  4. Brachmann CB, Sherman JM, Devine SE, Cameron EE, Pillus L and Boeke JD 1995 The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability. Genes Dev. 9 2888–2902CrossRefGoogle Scholar
  5. Cavalier-Smith T 1978 Nuclear volume control by nucleoskeletal DNA, selection for cell volume and cell growth rate, and the solution of the DNA C-value paradox. J. Cell Sci. 34 247–278PubMedGoogle Scholar
  6. Cernilogar FM and Orlando V 2005 Epigenome programming by Polycomb and Trithorax proteins. Biochem. Cell Biol. 83 322–331PubMedCrossRefGoogle Scholar
  7. Chen CC, Carson JJ, Feser J, Tamburini B, Zabaronick S, Linger J and Tyler JK 2008 Acetylated lysine 56 on histone H3 drives chromatin assembly after repair and signals for the completion of repair. Cell 134 231–243PubMedCrossRefGoogle Scholar
  8. Chiang T, Duncan FE, Schindler K, Schultz RM and Lampson MA 2010 Evidence that weakened centromere cohesion is a leading cause of age-related aneuploidy in oocytes. Curr. Biol. 20 1522–1528PubMedCrossRefGoogle Scholar
  9. Dang W, Steffen KK, Perry R, Dorsey JA, Johnson FB, Shilatifard A, Kaeberlein M, Kennedy BK and Berger SL 2009 Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature (London) 459 802–807CrossRefGoogle Scholar
  10. Das C, Lucia MS, Hansen KC and Tyler JK 2009 CBP/p300-mediated acetylation of histone H3 on lysine 56. Nature (London) 459 113–117CrossRefGoogle Scholar
  11. Das C, Tyler JK and Churchill ME 2010 The histone shuffle: histone chaperones in an energetic dance. Trends Biochem. Sci. 35 476–489PubMedCrossRefGoogle Scholar
  12. Feser J, Truong D, Das C, Carson JJ, Kieft J, Harkness T and Tyler JK 2010 Elevated histone expression promotes life span extension. Mol. Cell 39 724–735PubMedCrossRefGoogle Scholar
  13. Fillingham J and Greenblatt JF 2008 A histone code for chromatin assembly. Cell 134 206–208PubMedCrossRefGoogle Scholar
  14. Furuyama T, Banerjee R, Breen TR and Harte PJ 2004 SIR2 is required for polycomb silencing and is associated with an E(Z) histone methyltransferase complex. Curr. Biol. 14 1812–1821PubMedCrossRefGoogle Scholar
  15. Gil J and Peters G 2006 Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all. Nat. Rev. Mol. Cell Biol. 7 667–677PubMedCrossRefGoogle Scholar
  16. Gil J, Bernard D and Peters G 2005 Role of polycomb group proteins in stem cell self-renewal and cancer. DNA Cell Biol. 24 117–125PubMedCrossRefGoogle Scholar
  17. Gullerova M and Proudfoot NJ 2008 Cohesin complex promotes transcriptional termination between convergent genes in S. pombe. Cell 132 983–995PubMedCrossRefGoogle Scholar
  18. Guney I and Sedivy JM 2006 Cellular senescence, epigenetic switches and c-Myc. Cell Cycle 5 2319–2323PubMedCrossRefGoogle Scholar
  19. Gunjan A and Verreault A 2003 A Rad53 kinase-dependent surveillance mechanism that regulates histone protein levels in S. cerevisiae. Cell 115 537–549PubMedCrossRefGoogle Scholar
  20. Guo WJ, Datta S, Band V and Dimri GP 2007 Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins. Mol. Biol. Cell 18 536–546PubMedCrossRefGoogle Scholar
  21. Jacobs JJ, Kieboom K, Marino S, DePinho RA and van Lohuizen M 1999 The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature (London) 397 164–168PubMedCrossRefGoogle Scholar
  22. Kaeberlein M, McVey M and Guarente L 1999 The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 13 2570–2580CrossRefGoogle Scholar
  23. Kennedy BK, Gotta M, Sinclair DA, Mills K, McNabb DS, Murthy M, Pak SM, Laroche T, Gasser SM and Guarente L 1997 Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae. Cell 89 381–391PubMedCrossRefGoogle Scholar
  24. Kenyon CJ 2010 The genetics of ageing. Nature (London) 464 504–512CrossRefGoogle Scholar
  25. Landry J, Sutton A, Tafrov ST, Heller RC, Stebbins J, Pillus L and Sternglanz R 2000 The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc. Natl. Acad. Sci. USA 97 5807–5811PubMedCrossRefGoogle Scholar
  26. Lister LM, Kouznetsova A, Hyslop LA, Kalleas D, Pace SL, Barel JC, Nathan A, Floros V, Adelfalk C, Watanabe Y, et al. 2010 Age-related meiotic segregation errors in Mammalian oocytes are preceded by depletion of cohesin and Sgo2. Curr. Biol. 20 1511–1521PubMedCrossRefGoogle Scholar
  27. Lupo R, Breiling A, Bianchi ME and Orlando V 2001 Drosophila chromosome condensation proteins Topoisomerase II and Barren colocalize with Polycomb and maintain Fab-7 PRE silencing. Mol. Cell 7 127–136PubMedCrossRefGoogle Scholar
  28. Moazed D 2001 Enzymatic activities of Sir2 and chromatin silencing. Curr. Opin. Cell Biol. 13 232–238PubMedCrossRefGoogle Scholar
  29. Mousson F, Ochsenbein F and Mann C 2007 The histone chaperone Asf1 at the crossroads of chromatin and DNA checkpoint pathways. Chromosoma 116 79–93PubMedCrossRefGoogle Scholar
  30. Muller J, Hart CM, Francis NJ, Vargas ML, Sengupta A, Wild B, Miller EL, O’Connor MB, et al. 2002 Histone methyltransferase activity of a Drosophila Polycomb group repressor complex. Cell 111 197–208PubMedCrossRefGoogle Scholar
  31. Osley MA 1991 The regulation of histone synthesis in the cell cycle. Annu. Rev. Biochem. 60 827–861PubMedCrossRefGoogle Scholar
  32. O’Sullivan RJ, Kubicek S, Schreiber SL and Karlseder J 2010 Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres. Nat. Struct. Mol. Biol. 17 1218–1225CrossRefGoogle Scholar
  33. Ransom M, Williams SK, Dechassa ML, Das C, Linger J, Adkins M, Liu C, Bartholomew B and Tyler JK 2009 FACT and the proteasome promote promoter chromatin disassembly and transcriptional initiation. J. Biol. Chem. 284 23461–23471PubMedCrossRefGoogle Scholar
  34. Ringrose L and Paro R 2007 Polycomb/Trithorax response elements and epigenetic memory of cell identity. Development 134 223–232PubMedCrossRefGoogle Scholar
  35. Rosenberg MI and Parkhurst SM 2002 Drosophila Sir2 is required for heterochromatic silencing and by euchromatic Hairy/E(Spl) bHLH repressors in segmentation and sex determination. Cell 109 447–458PubMedCrossRefGoogle Scholar
  36. Sinclair DA and Guarente L 1997 Extrachromosomal rDNA circles–a cause of aging in yeast. Cell 91 1033–1042PubMedCrossRefGoogle Scholar
  37. Spector MS, Raff A, DeSilva H, Lee K and Osley MA 1997 Hir1p and Hir2p function as transcriptional corepressors to regulate histone gene transcription in the Saccharomyces cerevisiae cell cycle. Mol. Cell Biol. 17 545–552PubMedGoogle Scholar
  38. Steinkraus KA, Kaeberlein M and Kennedy BK 2008 Replicative aging in yeast: the means to the end. Annu. Rev. Cell Dev. Biol. 24 29–54PubMedCrossRefGoogle Scholar
  39. Taddei A, Van Houwe G, Nagai S, Erb I, van Nimwegen E and Gasser SM 2009 The functional importance of telomere clustering: global changes in gene expression result from SIR factor dispersion. Genome Res. 19 611–625PubMedCrossRefGoogle Scholar
  40. Tie F, Furuyama T, Prasad-Sinha J, Jane E and Harte PJ 2001 The Drosophila Polycomb Group proteins ESC and E(Z) are present in a complex containing the histone-binding protein p55 and the histone deacetylase RPD3. Development 128 275–286PubMedGoogle Scholar
  41. Tyler JK, Adams CR, Chen SR, Kobayashi R, Kamakaka RT and Kadonaga JT 1999 The RCAF complex mediates chromatin assembly during DNA replication and repair. Nature (London) 402 555–560CrossRefGoogle Scholar
  42. Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M and Sinclair D 2004 Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature (London) 430 686–689CrossRefGoogle Scholar
  43. Wood AJ, Severson AF and Meyer BJ 2010 Condensin and cohesin complexity: the expanding repertoire of functions. Nat. Rev. Genet. 11 391–404PubMedCrossRefGoogle Scholar

Copyright information

© Indian Academy of Sciences 2011

Authors and Affiliations

  1. 1.Centre for Cellular and Molecular Biology, CSIRHyderabadIndia

Personalised recommendations