References
Bozzetti M P, Massari S, Finelli P, Meggio F, Pinna L A, Boldyreff B, Issinger O-G, Palumbo G, et al. 1995 The Ste locus, a component of the parasitic cry-Ste system of Drosophila melanogaster, encodes a protein that forms crystals in primary spermatocytes and mimics properties of the β-subunit of casein kinase 2; Proc. Natl. Acad. Sci. USA 92 6067–6071
Kohanski M A, Depristo M A and Collins J J 2010 Sublethal antibiotic treatment leads to multidrug resistance via radical-induced mutagenesis; Mol. Cell. 37 311–320
McClintock B 1984 The significance of responses of the genome to challenge; Science 226 792–801
Rutherford S L and Lindquist S 1998 Hsp90 as a capacitor for morphological evolution; Nature (London) 396 336–342
Rutherford S L, Hirate Y and Swalla B 2007 The Hsp90 capacitor, developmental remodeling, and evolution: the robustness of gene networks and the curious evolvability of metamorphosis; Crit. Rev. Biochem. Mol. Biol. 42 355–372
Sangster T A, Lindquist S and Queitsch C 2004 Under cover: causes, effects and implications of Hsp90-mediated genetic capacitance; Bioessays 26 348–362
Sollars V, Lu X, Xiao L, Wang X, Garfinkel M D and Ruden D M 2003 Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitor for morphological evolution; Nat. Genet. 33 70–74
Specchia V, Piacentini L, Tritto P, Fanti L, D’Alessandro R, Palumbo G, Pimpinell S and Bozzetti M P 2010 Hsp90 prevents phenotypic variation by suppressing the mutagenic activity of transposons; Nature (London) 463 662–665
Waddington C H 1959 Canalization of development and genetic assimilation of acquired characters; Nature (London) 183 1654–1655
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Sawarkar, R., Paro, R. Heat shock protein 90: a capacitor or a mutator?. J Biosci 35, 163–165 (2010). https://doi.org/10.1007/s12038-010-0018-2
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DOI: https://doi.org/10.1007/s12038-010-0018-2