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Secreted Glycoproteins That Regulate Synaptic Function: the Dispatchers in the Central Nervous System

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Abstract

Glycoproteins are proteins that contain oligosaccharide chains. As widely distributed functional proteins in the body, glycoproteins are essential for cellular development, cellular function maintenance, and intercellular communication. Glycoproteins not only play a role in the cell and the membrane, but they are also secreted in the intercell. These secreted glycoproteins are critical to the central nervous system for neurodevelopment and synaptic transmission. More specifically, secreted glycoproteins play indispensable roles in neurite growth mediation, axon guiding, synaptogenesis, neuronal differentiation, the release of synaptic vesicles, subunit composition of neurotransmitter receptors, and neurotransmitter receptor trafficking among other things. Abnormal expressions of secreted glycoproteins in the central nervous system are associated with abnormal neuron development, impaired synaptic organization/transmission, and neuropsychiatric disorders. This article reviews the secreted glycoproteins that regulate neuronal development and synaptic function in the central nervous system, and the molecular mechanism of these regulations, providing reference for research about synaptic function regulation and related central nervous system diseases.

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Funding

This study was funded by the Graduate Student Scientific Research Innovation Projects in Jiangsu Province (grant No. KYCX22_1928).

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Authors and Affiliations

  1. School of Traditional Chinese Medicine, Capital Medical University, Beijing, China

    Haiying Gong

  2. Department of Pharmacy, Fuyang People’s Hospital, Fuyang, Anhui, China

    Conglei Zhu

  3. Department of Respiratory and Critical Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China

    Di Han

  4. School of Basic Medical Sciences, Beijing Key Laboratory of Neural Regeneration and Repair, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China

    Sen Liu

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This review was designed by Sen Liu and Haiying Gong. Haiying Gong conceived the article and revised the manuscript. Liu Sen analyzed the data, wrote the manuscript, and revised the revision. Conglei Zhu and Di Han modified the pictures. All authors read and approved the final manuscript.

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Gong, H., Zhu, C., Han, D. et al. Secreted Glycoproteins That Regulate Synaptic Function: the Dispatchers in the Central Nervous System. Mol Neurobiol 61, 2719–2727 (2024). https://doi.org/10.1007/s12035-023-03731-y

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