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The Role of Extrasynaptic GABA Receptors in Postpartum Depression

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Abstract

Postpartum depression is a serious disease with a high incidence and severe impact on pregnant women and infants, but its mechanism remains unclear. Recent studies have shown that GABA receptors, especially extrasynaptic receptors, are closely associated with postpartum depression. There are many different structures of GABA receptors, so different types of receptors have different functions, even though they transmit information primarily through GABA. In this review, we focus on the function of GABA receptors, especially extrasynaptic GABA receptors, and their association with postpartum depression. We have shown that the extrasynaptic GABA receptor has a significant impact on the activity and function of neurons through tonic inhibition. The extrasynaptic receptor and its ligands undergo drastic changes during pregnancy and childbirth. Abnormal changes or the body’s inability to adjust and recover may be an important cause of postpartum depression. Finally, by reviewing the mechanisms of several novel antidepressants, we suggest that extrasynaptic receptors may be potential targets for the treatment of postpartum depression.

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Data Availability

The data that support the findings of this study are available from the corresponding author.

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Acknowledgements

The authors would like to thank SaiYing Wang of the Third Xiangya Hospital of Central South University for helpful discussions on topics related to this work. We thank the editor and the reviewers for their useful feedback that improved this paper.

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  1. Third Xiangya Hospital of Central South University, Changsha, 410013, China

    Yun Fei Feng, Yin Yong Zhou & Kai Ming Duan

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All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Yun Fei Feng, Kai Ming Duan, and Yin Yong Zhou. The first draft of the manuscript was written by Yun Fei Feng and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Kai Ming Duan.

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Feng, Y.F., Zhou, Y.Y. & Duan, K.M. The Role of Extrasynaptic GABA Receptors in Postpartum Depression. Mol Neurobiol 61, 385–396 (2024). https://doi.org/10.1007/s12035-023-03574-7

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