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Revisiting the Role of Biologically Active Natural and Synthetic Compounds as an Intervention to Treat Injured Nerves

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Abstract

Traumatic lesions in nerves present high incidence and may culminate in sensorimotor and/or autonomic dysfunctions or a total loss of function, affecting the patient’s quality of life. Although the microenvironment favors peripheral nerve regeneration, the regenerative process is not always successful. Some herbs, natural products, and synthetic drugs have been studied as potential pro-regenerative interventions. We reviewed and discussed the most recent articles published over the last ten years in high impact factor journals. Even though most of the articles contemplated in this review were in vitro and animal model studies, those with herbs showed promising results. Most of them presented antioxidant and anti-inflammatory effects. Drugs of several pharmacological classes also showed optimistic outcomes in nerve functional recovery, including clinical trials. The results are hopeful; however, mechanisms of action need to be elucidated, and there is a need for more high-quality clinical studies. The study presents careful compilation of findings of dozens of compounds with consistent pro-regenerative evidence published in respected scientific journals. It may be valuable for health professionals and researchers in the field.

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Acknowledgements

Consejo Nacional de Ciencia y Tecnología (CONACYT) is thankfully acknowledged for partially supporting this work under Sistema Nacional de Investigadores (SNI) program awarded to Hafiz M.N. Iqbal (CVU: 735340). The authors thankfully acknowledge the literature access provided by their respective institutions/organizations.

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Authors and Affiliations

  1. Department of Medicine, Federal University of Juiz de Fora, Governador Valadares, Minas Gerais, 35032-620, Brazil

    Natália Melo Souza & Mateus Figueiredo Gonçalves

  2. Graduate Program in Process Engineering, Tiradentes University (UNIT), Av. Murilo Dantas, Aracaju Sergipe, Farolândia, 30049032-490, Brazil

    Luiz Fernando Romanholo Ferreira

  3. Institute of Technology and Research (ITP), Tiradentes University (UNIT), Av. Murilo Dantas, Aracaju-Sergipe, Farolândia, 30049032-490, Brazil

    Luiz Fernando Romanholo Ferreira

  4. School of Life Science and Food Engineering, Huaiyin Institute of Technology, Huaian, 223003, China

    Muhammad Bilal

  5. Tecnologico de Monterrey, School of Engineering and Sciences, 64849, Monterrey, Mexico

    Hafiz M. N. Iqbal

  6. Division of Physiology and Biophysics, Department of Basic Life Sciences, Federal University of Juiz de Fora, Governador Valadares, Minas Gerais, 35010-177, Brazil

    Renato Nery Soriano

Authors
  1. Natália Melo Souza
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  2. Mateus Figueiredo Gonçalves
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  3. Luiz Fernando Romanholo Ferreira
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  4. Muhammad Bilal
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  5. Hafiz M. N. Iqbal
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  6. Renato Nery Soriano
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Contributions

All listed authors equally contributed from conceptualization to compilation.

Corresponding authors

Correspondence to Muhammad Bilal, Hafiz M. N. Iqbal or Renato Nery Soriano.

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Souza, N.M., Gonçalves, M.F., Ferreira, L.F.R. et al. Revisiting the Role of Biologically Active Natural and Synthetic Compounds as an Intervention to Treat Injured Nerves. Mol Neurobiol 58, 4980–4998 (2021). https://doi.org/10.1007/s12035-021-02473-z

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