Molecular Neurobiology

, Volume 56, Issue 10, pp 6902–6927 | Cite as

Secretome of Mesenchymal Stem Cells and Its Potential Protective Effects on Brain Pathologies

  • Eliana Baez-Jurado
  • Oscar Hidalgo-Lanussa
  • Biviana Barrera-Bailón
  • Amirhossein Sahebkar
  • Ghulam Md Ashraf
  • Valentina Echeverria
  • George E. BarretoEmail author


Previous studies have indicated that mesenchymal stem cells (MSCs) have a fundamental role in the repair and regeneration of damaged tissues. There is strong evidence showing that much of the beneficial effects of these cells are due to the secretion of bioactive molecules—besides microRNAs, hormones, and neurotrophins—with anti-inflammatory, immunoregulatory, angiogenic, and trophic effects. These factors have been reported by many studies to possess protective effects on the nervous tissue. Although the beneficial effects of the secretory factors of MSCs have been suggested for various neurological diseases, their actions on astrocytic cells are not well understood. Hence, it is important to recognize the specific effects of MSCs derived from adipose tissue, in addition to the differences presented by the secretome, depending on the source and methods of analysis. In this paper, the different sources of MSCs and their main characteristics are described, as well as the most significant advances in regeneration and protection provided by the secretome of MSCs. Also, we discuss the possible neuroprotective mechanisms of action of the MSC-derived biomolecules, with special emphasis on the effect of MSCs derived from adipose tissue and their impact on glial cells and brain pathologies.


Mesenchymal stem cells Paracrine factors Pathologies Therapeutics Secretome Brain 



Adult stem cells


Amniotic fluid stem cells


Central nervous system


Conditioned medium of mesenchymal cells derived from adipose tissue


Conditioned medium of mesenchymal stem cells derived from bone marrow


Conditioned medium of mesenchymal stem cells


Dental plug stem cells


Embryonic stem cells


Epithelial stem cells


Fetal stem cells


Hematopoietic stem cells


Hepatic stem cells




Induced pluripotent stem cells


Mesenchymal cells derived from adipose tissue


Mesenchymal stem cells


Mesenchymal stem cells derived from bone marrow


Mesenchymal stem cells of the human umbilical cord


Mesenchymal stromal cells derived from the limbus


Neural stem cells


Pluripotent stem cells


Oxygen species


Reactive nitrogen species


Spinal cord injury


Traumatic brain injury


Umbilical cord blood


Umbilical cord stem cells


Umbilical cord stem cells


Wharton gelatin stem cells



This work was in part funded by PUJ grant (ID no. 7115) to GEB. We also acknowledge scholarships for doctoral studies granted by the Vicerrectoría Académica of PUJ to Baez-Jurado E and Hidalgo-Lanussa O.

Compliance with Ethical Standards

Conflict of Interest

The authors declare no conflicts of interest.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Departamento de Nutrición y Bioquímica, Facultad de CienciasPontificia Universidad JaverianaBogotáColombia
  2. 2.Neurogenic Inflammation Research CenterMashhad University of Medical SciencesMashhadIran
  3. 3.Biotechnology Research Center, Pharmaceutical Technology InstituteMashhad University of Medical SciencesMashhadIran
  4. 4.School of PharmacyMashhad University of Medical SciencesMashhadIran
  5. 5.King Fahd Medical Research CenterKing Abdulaziz UniversityJeddahSaudi Arabia
  6. 6.Facultad de Ciencias de la SaludUniversidad San SebastianConcepciónChile
  7. 7.Research & Development ServiceBay Pines VA Healthcare SystemBay PinesUSA

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