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Development of Cortical Pyramidal Cell and Interneuronal Dendrites: a Role for Kainate Receptor Subunits and NETO1

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Abstract

During neuronal development, AMPA receptors (AMPARs) and NMDA receptors (NMDARs) are important for neuronal differentiation. Kainate receptors (KARs) are closely related to AMPARs and involved in the regulation of cortical network activity. However, their role for neurite growth and differentiation of cortical neurons is unclear. Here, we used KAR agonists and overexpression of selected KAR subunits and their auxiliary neuropilin and tolloid-like proteins, NETOs, to investigate their influence on dendritic growth and network activity in organotypic cultures of rat visual cortex. Kainate at 500 nM enhanced network activity and promoted development of dendrites in layer II/III pyramidal cells, but not interneurons. GluK2 overexpression promoted dendritic growth in pyramidal cells and interneurons. GluK2 transfectants were highly active and acted as drivers for network activity. GluK1 and NETO1 specifically promoted dendritic growth of interneurons. Our study provides new insights for the roles of KARs and NETOs in the morphological and physiological development of the visual cortex.

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Acknowledgements

We thank Andrea Räk, Sabine Schönfelder, and Christian Riedel for technical support. We thank Prof. Nathalie Strutz-Seebohm, University Münster, for providing the TTBK2-KD plasmid. We thank Prof. Andreas Reiner, Ruhr University Bochum, for discussion. We thank Bente Janssen-Weets and Felix Burgmann for help with reconstructions during their BSc thesis work.

Funding

Supported by Deutsche Forschungsgemeinschaft grants WA 541/9-1 and 541/9-2.

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Authors and Affiliations

  1. Faculty for Biology and Biotechnology ND 6/72, Developmental Neurobiology, Ruhr University Bochum, Universitätsstraße 150, 44801, Bochum, Germany

    Alexander Jack, Mohammad I. K. Hamad, Steffen Gonda, Sebastian Gralla & Petra Wahle

  2. Medical Faculty, Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Universitätsstraße 150, 44801, Bochum, Germany

    Mohammad I. K. Hamad

  3. Faculty of Chemistry and Biochemistry, Biochemistry I—Receptor Biochemistry, Ruhr University Bochum, Universitätsstraße 150, 44801, Bochum, Germany

    Steffen Pahl & Michael Hollmann

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  5. Steffen Pahl
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  6. Michael Hollmann
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  7. Petra Wahle
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Contributions

AJ, MIKH, and PW designed experiments. AJ, MIKH, SG, SG, SP, and PW performed experiments. AJ and PW did the data management and interpretation. AJ and PW wrote the manuscript. MH commented on the manuscript. All authors approved the final version.

Corresponding author

Correspondence to Petra Wahle.

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The authors declare that they do not have any conflict of interest.

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Jack, A., Hamad, M.I.K., Gonda, S. et al. Development of Cortical Pyramidal Cell and Interneuronal Dendrites: a Role for Kainate Receptor Subunits and NETO1. Mol Neurobiol 56, 4960–4979 (2019). https://doi.org/10.1007/s12035-018-1414-0

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  • DOI: https://doi.org/10.1007/s12035-018-1414-0

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