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Kinesins: Motor Proteins as Novel Target for the Treatment of Chronic Pain

  • P. A. Shantanu
  • Dilip Sharma
  • Monika Sharma
  • Shivani Vaidya
  • Kuhu Sharma
  • Kiran Kalia
  • Yuan-Xiang Tao
  • Amit Shard
  • Vinod Tiwari
Article

Abstract

Kinesins are one of the neoteric and efficacious targets recently reported to play an important role in the initiation and progression of chronic pain. Kinesins are anterograde microtubule-based motor proteins that are involved in trafficking of receptors including nociceptors and progression of pain. The specific kinesin and regulatory proteins interplay is crucial for the delivery of nociceptors to the synapse. If this complex and less understood interplay is inhibited, it may result in a decrease in central sensitization, and thus attenuation of pain. This review is focused on the transportation process of receptors/cargos, the role of regulatory proteins influencing the respective kinesin, and their relationship with chronic pain. The review also features specific strategies adopted by researchers for targeting kinesin and chronic pain. Considering the recent preclinical success of kinesin inhibition in pain, it is expected that inhibitors for kinesin or enzymes responsible for kinesin activation could be developed or repurposed as alternative, safe, and potential therapies for the treatment of chronic pain.

Keywords

Bone cancer pain Calcium calmodulin kinase 2 Cyclin-dependent kinesins KIF13B KIF17 NMDA, pain Sodium channels TRPV1 

Notes

Acknowledgements

The authors wish to express their thanks to Prof. D.K. Singh for his editorial contribution and to the Director, NIPER Ahmedabad for providing necessary facilities and infrastructure.

Funding

This work is supported by Department of Pharmaceuticals, Ministry of Chemical and Fertilizers, Govt of India, National Institute of Pharmaceutical Education and Research (NIPER) Ahmedabad, Gandhinagar, Gujarat, India and Department of Science and Technology (DST), Government of India, Early Career Research Grant (ECR/2016/001846) awarded to Dr. Vinod Tiwari and by NIH grants (R01NS094664, R01NS094224, and R01DA033390) for Yuan-Xiang Tao.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Pharmacology and ToxicologyNational Institute of Pharmaceutical Education and Research (NIPER)-AhmedabadGandhinagarIndia
  2. 2.Neurosicience Research InstituteZhengzhou University Academy of Medical SciencesZhengzhouChina
  3. 3.Department of Anesthesiology, New Jersey Medical School, RutgersThe State University of New JerseyNewarkUSA
  4. 4.Department of Medicinal ChemistryNational Institute of Pharmaceutical Education and Research (NIPER)-AhmedabadGandhinagarIndia

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