Abscisic Acid Supplementation Rescues High Fat Diet-Induced Alterations in Hippocampal Inflammation and IRSs Expression

Molecular Neurobiology volume 56, pages454–464(2019)Cite this article

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Abstract

Accumulated evidence indicates that neuroinflammation induces insulin resistance in the brain. Moreover, both processes are intimately linked to neurodegenerative disorders, including Alzheimer’s disease. Potential mechanisms underlying insulin resistance include serine phosphorylation of the insulin receptor substrate (IRS) or insulin receptor (IR) misallocation. However, only a few studies have focused on IRS expression in the brain and its modulation in neuroinflammatory processes. This study used the high-fat diet (HFD) model of neuroinflammation to study the alterations of IR, an insulin-like growth factor receptor (IGF1R) and IRS expressions in the hippocampus. We observed that HFD effectively reduced mRNA and protein IRS2 expression. In contrast, a HFD induced the upregulation of the IRS1 mRNA levels, but did not alter an IR and IGF1R expression. As expected, we observed that a HFD increased hippocampal tumor necrosis factor alpha (TNFα) and amyloid precursor protein (APP) levels while reducing brain-derived neurotrophic factor (BDNF) expression and neurogenesis. Interestingly, we found that TNFα correlated positively with IRS1 and negatively with IRS2, whereas APP levels correlated positively only with IRS1 but not IRS2. These results indicate that IRS1 and IRS2 hippocampal expression can be affected differently by HFD-induced neuroinflammation. In addition, we aimed to establish whether abscisic acid (ABA) can rescue hippocampal IRS1 and IRS2 expression, as we had previously shown that ABA supplementation prevents memory impairments and improves neuroinflammation induced by a HFD. In this study, ABA restored HFD-induced hippocampal alterations, including IRS1 and IRS2 expression, TNFα, APP, and BDNF levels and neurogenesis. In conclusion, this study highlights different regulations of hippocampal IRS1 and IRS2 expression using a HFD, indicating the important differences of these scaffolding proteins, and strongly supports ABA therapeutic effects.

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Change history

  • 26 February 2019

    The author missed to include the second affiliation of Mariam Atef to the original paper published. With this, the authors published this correction.

Abbreviations

ABA:

Abscisic acid

ANOVA:

Analysis of variance

APP:

Amyloid precursor protein

BDNF:

Brain-derived neurotrophic factor

ERK:

Extracellular regulated kinases

HFD:

High-fat diet

IGF1:

Insulin-like growth factor

IGF1R:

Insulin-like growth factor receptor

IR:

Insulin receptor

IRS:

Insulin receptor substrate

PFA:

Paraformaldehyde

PPAR-γ:

Peroxisome proliferator-activated receptor gamma

RTqPCR:

Real-time quantitative polymerase chain reaction

SEM:

Standard error of mean

SD:

Standard diet

SGZ:

Subgranular zone

TBS:

Tris-buffered saline

TDZ:

Thiazolidinediones

TNFα:

Tumor necrosis factor alpha

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Funding

This work was supported by Plan Propi Universitat Jaume I P1.1A2014-06 and Generalitat Valenciana GVA AICO/2015/042 to AMSP. The authors want to thank the generous donations to Crowdfunding Precipita (FECYT) and the Association of Alzheimer Families, AFA, Castellon.

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Affiliations

  1. Department of Medicine, University of Jaume I, Castellón de la Plana, Spain

    Alberto Ribes-Navarro, Mariam Atef, Sandra Sánchez-Sarasúa, María Teresa Beltrán-Bretones, Francisco Olucha-Bordonau & Ana María Sánchez-Pérez

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  1. Alberto Ribes-Navarro
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  2. Mariam Atef
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  3. Sandra Sánchez-Sarasúa
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  4. María Teresa Beltrán-Bretones
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  5. Francisco Olucha-Bordonau
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  6. Ana María Sánchez-Pérez
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Correspondence to Ana María Sánchez-Pérez.

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Ribes-Navarro, A., Atef, M., Sánchez-Sarasúa, S. et al. Abscisic Acid Supplementation Rescues High Fat Diet-Induced Alterations in Hippocampal Inflammation and IRSs Expression. Mol Neurobiol 56, 454–464 (2019). https://doi.org/10.1007/s12035-018-1091-z

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Keywords

  • Insulin resistance
  • Hippocampus
  • APP
  • BDNF
  • Neurogenesis
  • Neuroinflammation