TRPV4: a Sensor for Homeostasis and Pathological Events in the CNS

  • Hemant Kumar
  • Soo-Hong Lee
  • Kyoung-Tae Kim
  • Xiang Zeng
  • Inbo Han


Transient receptor potential vanilloid type 4 (TRPV4) was originally described as a calcium-permeable nonselective cation channel. TRPV4 is now recognized as a polymodal ionotropic receptor: it is a broadly expressed, nonselective cation channel (permeable to calcium, potassium, magnesium, and sodium) that plays an important role in a multitude of physiological processes. TRPV4 is involved in maintaining homeostasis, serves as an osmosensor and thermosensor, can be activated directly by endogenous or exogenous chemical stimuli, and can be activated or sensitized indirectly via intracellular signaling pathways. Additionally, TRPV4 is upregulated in a variety of pathological conditions. In this review, we focus on the role of TRPV4 in mediating homeostasis and pathological events in the central nervous system (CNS). This review is composed of three parts. Section 1 describes the role of TRPV4 in maintaining homeostatic processes, including the volume of body water, ionic concentrations, volume, and the temperature. Section 2 describes the effects of activation and inhibition of TRPV4 in the CNS. Section 3 focuses on the role of TRPV4 during pathological events in CNS.


TRPV4 CNS Glia Homeostasis Osmosensor Thermosensor Calcium signaling 



This work was supported by a grant of the National Research Foundation of Korea (NRF) (NRF-2015H1D3A1066543, NRF-2017R1C1B2011772) and the Korea Healthcare Technology Research & Development Project, Ministry for Health & Welfare Affairs, Republic of Korea (HR16C0002).


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of NeurosurgeryCHA University, CHA Bundang Medical CenterSeongnam-siRepublic of Korea
  2. 2.Department of Biomedical ScienceCHA UniversitySeongnam-siRepublic of Korea
  3. 3.Department of NeurosurgeryKyungpook National University HospitalDaeguRepublic of Korea
  4. 4.Department of Histology and Embryology, Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouChina

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