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Neuroinflammation, Gut Microbiome, and Alzheimer’s Disease

Abstract

Alzheimer’s disease (AD) is a progressive neurodegenerative disease that develops insidiously and causes dementia finally. There are also clinical complications in advanced dementia, such as eating problems, infections, which will lead to the decline of patients’ life quality, and the rising cost of care for AD to our society. AD will be important public health challenge. Early detection of AD may be a key issue to prevent, delay, and stop the disease. Gut microbiome and neuroinflammation are closely related with nervous system diseases, although the specific mechanism is not clear. This review introduces the relationship between neuroinflammation, gut microbiome, and AD.

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Acknowledgements

Supported by grants from the National Natural Science Foundation of China (grant nos. 81322020 and 81230032 to L.J.Z.).

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Correspondence to Long Jiang Zhang.

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Lin, L., Zheng, L.J. & Zhang, L.J. Neuroinflammation, Gut Microbiome, and Alzheimer’s Disease. Mol Neurobiol 55, 8243–8250 (2018). https://doi.org/10.1007/s12035-018-0983-2

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Keywords

  • Alzheimer’s disease
  • Gut microbiome
  • Neuroinflammation