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RIT2 Polymorphisms: Is There a Differential Association?

Molecular Neurobiology volume 54, pages 2234–2240 (2017)Cite this article

Abstract

Neurological disorders include a wide variety of mostly multifactorial diseases related to the development, survival, and function of the neuron cells. Single-nucleotide polymorphisms (SNPs) have been extensively studied in neurological disorders, and in a number of instances have been reproducibly linked to disease as risk factors. The RIT2 gene has been recently shown to be associated with a number of neurological disorders, such as Parkinson’s disease (PD) and autism. In the study reported here, we investigated the association of the rs12456492 and rs16976358 SNPs of the RIT2 gene with PD, essential tremor (ET), autism, schizophrenia (SCZ), and bipolar disorder (BPD; total of 2290 patients), and 1000 controls, by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Significant association was observed between rs12456492 and two disorders, PD and ET, whereas rs16976358 was found to be associated with autism, SCZ, and BPD. Our findings are indicative of differential association between the RIT2 SNPs and different neurological disorders.

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Acknowledgments

We would like to thank our patients and their families for their participation in this study.

Author information

Affiliations

  1. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Babak Emamalizadeh, Abolfazl Movafagh, Shaghayegh Taghavi, Marzieh Motallebi, Atena Fazeli, Azadeh Ahmadifard, Tannaz Safaralizadeh, Amir Ehtesham Shafiei Zarneh, Monavvar Andarva, Elham Alehabib, Minoo Atakhorrami & Hossein Darvish

  2. Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran

    Javad Jamshidi

  3. Iranian Research Center on Aging, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran

    Mina Ohadi

  4. Department of Medical Genetics, Faculty of Medicine, Tabriz University of medical Sciences, Tabriz, Iran

    Mahmoud Shekari khaniani

  5. Neurosciences Research Center, Tabriz University of medical Sciences, Tabriz, Iran

    Mahmoud Shekari khaniani

  6. Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran

    Somayyeh Kazeminasab

  7. Department of Biostatistics, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran

    Akbar Biglarian

  8. Movement Disorders Clinic, Hazrat Rassol Hospital, Iran University of Medical Sciences, Tehran, Iran

    Gholam-Ali Shahidi

  9. Department of Neurology, Shiraz University of Medical Sciences, Shiraz, Iran

    Peyman Petramfar

  10. Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran

    Neda Shahmohammadibeni, Tahereh Dadkhah & Ehteram Khademi

  11. Department of Neurology, School of Medicine, Imam Khomeini Hospital and Iranian Center of Neurological Research, Tehran University of Medical Sciences, Tehran, Iran

    Abbas Tafakhori

  12. Sabzevar University of Medical Sciences, Sabzevar, Iran

    Ali Khaligh

  13. Stem Cell Research Center, Golestan University of Medical Sciences, Gorgan, Iran

    Ali Kowsari

  14. Department of Psychiatry, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran

    Arash Mirabzadeh

  15. Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

    Mehdi Khorrami

  16. Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran

    Parasto Shokraeian

  17. Department of Microbiology, Kerman Branch, Islamic Azad University, Kerman, Iran

    Mohammad Javad Soltani Banavandi

  18. Department of Neurology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Behnam Safarpour Lima

Authors
  1. Babak Emamalizadeh
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  2. Javad Jamshidi
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  3. Abolfazl Movafagh
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  4. Mina Ohadi
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  5. Mahmoud Shekari khaniani
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  6. Somayyeh Kazeminasab
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  8. Shaghayegh Taghavi
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  9. Marzieh Motallebi
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  12. Gholam-Ali Shahidi
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  14. Neda Shahmohammadibeni
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  18. Ali Khaligh
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  19. Tannaz Safaralizadeh
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  20. Ali Kowsari
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  21. Arash Mirabzadeh
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  22. Amir Ehtesham Shafiei Zarneh
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  25. Mohammad Javad Soltani Banavandi
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  26. Behnam Safarpour Lima
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  27. Monavvar Andarva
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  28. Elham Alehabib
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  29. Minoo Atakhorrami
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  30. Hossein Darvish
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Corresponding author

Correspondence to Hossein Darvish.

Ethics declarations

Written informed consent was taken from all participants. The study was approved by the ethic committee at Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Conflict of Interest

The authors declare that they have no conflict of interest.

Competing Financial Interests

The authors declare no competing financial interests.

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Emamalizadeh, B., Jamshidi, J., Movafagh, A. et al. RIT2 Polymorphisms: Is There a Differential Association?. Mol Neurobiol 54, 2234–2240 (2017). https://doi.org/10.1007/s12035-016-9815-4

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  • DOI: https://doi.org/10.1007/s12035-016-9815-4

Keywords

  • Neurological disorders
  • Parkinson’s disease
  • Essential tremor
  • Autism
  • Schizophrenia
  • Bipolar disorder
  • RIT2
  • Polymorphism