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Altered Amygdala Resting-State Functional Connectivity in Maintenance Hemodialysis End-Stage Renal Disease Patients with Depressive Mood

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Abstract

The purpose of this study was to investigate patterns in the amygdala-based emotional processing circuit of hemodialysis patients using resting-state functional MR imaging (rs-fMRI). Fifty hemodialysis patients (25 with depressed mood and 25 without depressed mood) and 26 healthy controls were included. All subjects underwent neuropsychological tests and rs-fMRI, and patients also underwent laboratory tests. Functional connectivity of the bilateral amygdala was compared among the three groups. The relationship between functional connectivity and clinical markers was investigated. Depressed patients showed increased positive functional connectivity of the left amygdala with the left superior temporal gyrus and right parahippocampal gyrus (PHG) but decreased amygdala functional connectivity with the left precuneus, angular gyrus, posterior cingulate cortex (PCC), and left inferior parietal lobule compared with non-depressed patients (P < 0.05, AlphaSim corrected). Depressed patients had increased positive functional connectivity of the right amygdala with bilateral supplementary motor areas and PHG but decreased amygdala functional connectivity with the right superior frontal gyrus, superior parietal lobule, bilateral precuneus, and PCC (P < 0.05, AlphaSim corrected). After including anxiety as a covariate, we discovered additional decreased functional connectivity with anterior cingulate cortex (ACC) for bilateral amygdala (P < 0.05, AlphaSim corrected). For the depressed, neuropsychological test scores were correlated with functional connectivity of multiple regions (P < 0.05, AlphaSim corrected). In conclusion, functional connectivity in the amygdala-prefrontal-PCC-limbic circuits was impaired in depressive hemodialysis patients, with a gradual decrease in ACC between controls, non-depressed, and depressed patients for the right amygdala. This indicates that ACC plays a role in amygdala-based emotional regulatory circuits in these patients.

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Acknowledgments

This work was supported by the grants from the Natural Scientific Foundation of China (Grant Nos. 81322020, 81230032, and 81171313 for Long Jiang Zhang) and the Program for New Century Excellent Talents in University (NCET-12-0260).

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Authors and Affiliations

  1. Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Zhongshan East Road, Xuanwu District, Nanjing, Jiangsu Province, 210002, China

    Hui Juan Chen, Yun Fei Wang, Rongfeng Qi, U. Joseph Schoepf, Xiang Kong, Guang Ming Lu & Long Jiang Zhang

  2. Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, MSC 226, 25 Courtenay Dr, Charleston, SC, 29401, USA

    U. Joseph Schoepf, Akos Varga-Szemes & B. Devon Ball

  3. National Clinical Research Center of Kidney Disease, Jinling Hospital, Medical School of Nanjing University, Nanjing, 210002, China

    Zhe Zhang, Jiqiu Wen & Xue Li

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  1. Hui Juan Chen
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  11. Guang Ming Lu
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  12. Long Jiang Zhang
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Corresponding author

Correspondence to Long Jiang Zhang.

Ethics declarations

This study was approved by the Local Medical Research Ethics Committee. All subjects gave informed consent before participating in the study.

Conflicts of Interest

UJS is a consultant for and/or receives research support from Astellas, Bayer, Bracco, GE, Guerbet, Medrad, and Siemens. The other authors have no conflicts of interest to declare.

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Chen, H.J., Wang, Y.F., Qi, R. et al. Altered Amygdala Resting-State Functional Connectivity in Maintenance Hemodialysis End-Stage Renal Disease Patients with Depressive Mood. Mol Neurobiol 54, 2223–2233 (2017). https://doi.org/10.1007/s12035-016-9811-8

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  • DOI: https://doi.org/10.1007/s12035-016-9811-8

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