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Adoptive Autophagy Activation: a Much-Needed Remedy Against Chemical Induced Neurotoxicity/Developmental Neurotoxicity

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Abstract

The profound significance of autophagy as a cell survival mechanism under conditions of metabolic stress is a well-proven fact. Nearly a decade-long research in this area has led scientists to unearth various roles played by autophagy other than just being an auto cell death mechanism. It is implicated as a vital cell survival pathway for clearance of all the aberrant cellular materials in case of cellular injury, metastasis, disease states, cellular stress, neurodegeneration and so on. In this review, we emphasise the critical role of autophagy in the environmental stressors-induced neurotoxicity and its therapeutic implications for the same. We also attempt to shed some light on the possible protective role of autophagy in developmental neurotoxicity (DNT) which is a rapidly growing health issue of the human population at large and hence a point of rising concern amongst researchers. The intimate association between DNT and neurodegenerative disorders strongly indicates towards adopting autophagy activation as a much-needed remedy for DNT.

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Acknowledgments

Financial support from Department of Science and Technology, Ministry of Science & Technology, Government of India, New Delhi, India (Grant No. SR/SO/Z 36/2007/91/10); Department of Biotechnology, Ministry of Science & Technology, Government of India, New Delhi, India (Grant No. 102/IFD/SAN/3533/2014-15) and Council of Scientific & Industrial Research, Government of India, New Delhi, India (Grant No. BSC0111/INDEPTH/CSIR Network Project) is acknowledged.

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Authors and Affiliations

  1. System Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), MG Marg, Lucknow, Uttar Pradesh, 226001, India

    A. Srivastava, V. Kumar, A. Pandey, S. Jahan, D. Kumar, C. S. Rajpurohit, S. Singh, V. K. Khanna & A. B. Pant

  2. BBD College of Dental Sciences, BBD University, Faizabad Road, Lucknow, Uttar Pradesh, 227015, India

    A. Srivastava

  3. Academy of Scientific & Innovative Research, CSIR-IITR Campus, Lucknow, India

    S. Jahan, D. Kumar, C. S. Rajpurohit, S. Singh, V. K. Khanna & A. B. Pant

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  1. A. Srivastava
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  2. V. Kumar
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Srivastava, A., Kumar, V., Pandey, A. et al. Adoptive Autophagy Activation: a Much-Needed Remedy Against Chemical Induced Neurotoxicity/Developmental Neurotoxicity. Mol Neurobiol 54, 1797–1807 (2017). https://doi.org/10.1007/s12035-016-9778-5

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