Abstract
Neurodegenerative diseases have been an unsolved riddle for quite a while; to date, there are no proper and effective curative treatments and only palliative and symptomatic treatments are available to treat these illnesses. The absence of therapeutic treatments for neurodegenerative ailments has huge economic hit and strain on the society. Pharmacotherapies and various surgical procedures like deep brain stimulation are being given to the patient, but they are only effective for the symptoms and not for the diseases. This paper reviews the recent studies and development of stem cell therapy for neurodegenerative disorders. Stem cell-based treatment is a promising new way to deal with neurodegenerative diseases. Stem cell transplantation can advance useful recuperation by delivering trophic elements that impel survival and recovery of host neurons in animal models and patients with neurodegenerative maladies. Several mechanisms, for example, substitution of lost cells, cell combination, release of neurotrophic factor, proliferation of endogenous stem cell, and transdifferentiation, may clarify positive remedial results. With the current advancements in the stem cell therapies, a new hope for the cure has come out since they have potential to be a cure for the same. This review compiles stem cell therapy recent conceptions in neurodegenerative and neurometabolic diseases and updates in this field.
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Abbreviations
- AD:
-
Alzheimer’s disease
- ALS:
-
Amyotrophic lateral sclerosis
- APP:
-
Amyloid precursor protein
- ARSA:
-
Arylsulfatase
- BDNF:
-
Brain-derived neurotrophic factor
- CAA:
-
Cerebral amyloid angiopathy
- CNS:
-
Central nervous system
- CTX:
-
Cerebrotendinous xanthomatosis
- DA:
-
Dopaminergic
- ESCs:
-
Embryonic stem cells
- GDNF:
-
Glial cell line-derived neurotrophic factor
- GFP:
-
Green fluorescent protein
- HD:
-
Huntington’s disease
- HTT:
-
Huntingtin gene
- iPSCs:
-
Induced pluripotent stem cells
- MLD:
-
Metachromatic leukodystrophy
- MNDs:
-
Motor neuron diseases
- MNs:
-
Motor neurons
- MRI:
-
Magnetic resonance imaging
- MSCs:
-
Mesenchymal stem cells
- NCL:
-
Neuronal ceroid lipofuscinoses
- ND:
-
Neurodegenerative disease
- NGF:
-
Nerve growth factor
- NPCs:
-
Neural progenitor cells
- NSCs:
-
Neural stem cells
- PD:
-
Parkinson’s disease
- PET:
-
Positron emission tomography
- PLS:
-
Primary lateral sclerosis
- PNS:
-
Peripheral nervous system
- SCA:
-
Spinocerebellar ataxia
- SCs:
-
Stem cells
- SCF:
-
Stem cell factor
- SCTs:
-
Stem cell therapies
- SMA:
-
Spinal muscular atrophy
- SPECT:
-
Single-photon emission computed tomography
- SVZ:
-
Subventricular zone
- TSD:
-
Tay-Sachs disease
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The Authors PP and BG like to acknowledge Ministry of Education (MOE) for Startup Grant and Tier 1 Grant. KN like to acknowledge Institute of Bioengineering and Nanotechnology, Singapore for funding. KJV like to acknowledge National Dental Centre research fund, Singapore.
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Kumar, A., Narayanan, K., Chaudhary, R.K. et al. Current Perspective of Stem Cell Therapy in Neurodegenerative and Metabolic Diseases. Mol Neurobiol 54, 7276–7296 (2017). https://doi.org/10.1007/s12035-016-0217-4
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DOI: https://doi.org/10.1007/s12035-016-0217-4