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Comparison of the Effect of Exercise on Late-Phase LTP of the Dentate Gyrus and CA1 of Alzheimer’s Disease Model

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A Correction to this article was published on 05 October 2017

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Abstract

We investigated the neuroprotective effect of regular treadmill exercise training on long-term memory and its correlate: the late-phase long-term potentiation (L-LTP) and plasticity- and memory-related signaling molecules in the DG and CA1 areas of a rat model of Alzheimer’s disease (AD) (i.c.v. infusion of Aβ1-42 peptides, 2 weeks, 250 pmol/day). Testing in the radial arm water maze revealed severe impairment of spatial long-term memory in Aβ-infused sedentary rats but not in exercised Aβ-infused rats. The L-LTP, measured as changes in the field (f)EPSP and in the amplitude of population spike (pspike), was induced by multiple high-frequency stimulation in the CA1 and DG areas of anesthetized rats. The L-LTP of fEPSP in both areas was severely impaired in the sedentary Aβ rats but not in exercised Aβ rats. However, L-LTP of the pspike was severely suppressed in the CA1 area but not in the DG of sedentary Aβ rats. Immunoblot analysis revealed no increase in the levels of phosphorylated (p)-CREB, CaMKIV, and brain-derived neurotrophic factor (BDNF) in both CA1 and DG areas of sedentary Aβ rats during L-LTP, whereas the levels of these molecules were robustly increased in exercised Aβ rats. Impairment of synaptic function may be due to deleterious changes in the molecular signaling cascades that mediate synaptic structural and functional changes. The protective effect of regular exercise can be a promising therapeutic measure for countering or delaying the AD-like pathology.

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Change history

  • 05 October 2017

    The original version of this article unfortunately does not include the second affiliating institution of Dr. Munder A. Zagaar. “Department of Pharmacy Pracce and Clinical Health Sciences, Texas Southern University, Houston, TX 77004” should have been included on the paper.

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Acknowledgments

This study was funded by several SGP grants from the University of Houston.

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Authors and Affiliations

  1. Department of PPS, College of Pharmacy, University of Houston, Houston, TX, 77204-5037, USA

    An T. Dao, Munder A. Zagaar, Amber T. Levine & Karim A. Alkadhi

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  1. An T. Dao
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  2. Munder A. Zagaar
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  3. Amber T. Levine
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  4. Karim A. Alkadhi
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Corresponding author

Correspondence to Karim A. Alkadhi.

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All animal experiments complied with the “National Research Council’s Guide of The Care and Use of Laboratory Animals” and with the approval of Institutional Animal Care and Use Committee at the University of Houston.

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The authors declare that they have no competing interests.

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A correction to this article is available online at https://doi.org/10.1007/s12035-017-0790-1.

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Dao, A.T., Zagaar, M.A., Levine, A.T. et al. Comparison of the Effect of Exercise on Late-Phase LTP of the Dentate Gyrus and CA1 of Alzheimer’s Disease Model. Mol Neurobiol 53, 6859–6868 (2016). https://doi.org/10.1007/s12035-015-9612-5

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