Endogenous Docosahexaenoic Acid (DHA) Prevents Aβ1–42 Oligomer-Induced Neuronal Injury
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The intake of the polyunsaturated fatty acid docosahexaenoic acid (DHA) or n-3 fatty acid has been associated with reduced risk of Alzheimer’s disease (AD) in epidemiological reports. However, the underlying mechanism remains to be elucidated. Here, we report that exogenous DHA administration could protect neurons against Aβ oligomer-induced injury both in vitro and in vivo, partly through reducing the endoplasmic reticulum (ER) stress, and preventing cell apoptosis. In transgenic fat-1 mice with enriched ω-3 fatty acids, Aβ oligomers induced fewer neuronal losses, when compared to wild-type (WT) mice. We conclude that endogenous DHA are neuroprotective in pathogenesis processes of AD.
KeywordsAlzheimer’s disease Aβ oligomers DHA Omega-3 Fat-1 mice
This study is supported by the Macao Science and Technology Development Fund (018/2013/A1), matching grant project MRG003/SHX/2014/ICMS, and multi-year research grant, university of Macau, MYRG122 (Y1-L3)-ICMS12-SHX and MYRG110 (Y1-L2)-ICMS13-SHX (H.S.). The study is also supported by “Hundred Talents program,” “Qing Lan Project” of Nanjing Normal University, and Jiangsu Provincial Natural Science Foundation (No. BK20140917) (T-F.Y.).
Conflicts of Interest
- 13.Lim WS, Gammack JK, Van Niekerk J, Dangour AD (2006) Omega 3 fatty acid for the prevention of dementia. Cochrane Database Syst Rev. 2006 (1):Cd005379Google Scholar
- 17.Fa M, Orozco IJ, Francis YI, Saeed F, Gong Y, Arancio O (2010) Preparation of oligomeric beta-amyloid 1-42 and induction of synaptic plasticity impairment on hippocampal slices. J Vis Exp 14:(41). doi: 10.3791/1884
- 27.Chiu CC, Su KP, Cheng TC, Liu HC, Chang CJ, Dewey ME et al (2008) The effects of omega-3 fatty acids monotherapy in Alzheimer’s disease and mild cognitive impairment: a preliminary randomized double-blind placebo-controlled study. Prog Neuropsychopharmacol Biol Psychiatry 32(6):1538–1544CrossRefPubMedGoogle Scholar