Molecular Neurobiology

, Volume 53, Issue 5, pp 3146–3153

Endogenous Docosahexaenoic Acid (DHA) Prevents Aβ1–42 Oligomer-Induced Neuronal Injury

  • Yuan Tan
  • Huixia Ren
  • Zhe Shi
  • Xiaoli Yao
  • Chengwei He
  • Jing-X Kang
  • Jian-Bo Wan
  • Peng Li
  • Ti-Fei Yuan
  • Huanxing Su
Article

DOI: 10.1007/s12035-015-9224-0

Cite this article as:
Tan, Y., Ren, H., Shi, Z. et al. Mol Neurobiol (2016) 53: 3146. doi:10.1007/s12035-015-9224-0

Abstract

The intake of the polyunsaturated fatty acid docosahexaenoic acid (DHA) or n-3 fatty acid has been associated with reduced risk of Alzheimer’s disease (AD) in epidemiological reports. However, the underlying mechanism remains to be elucidated. Here, we report that exogenous DHA administration could protect neurons against Aβ oligomer-induced injury both in vitro and in vivo, partly through reducing the endoplasmic reticulum (ER) stress, and preventing cell apoptosis. In transgenic fat-1 mice with enriched ω-3 fatty acids, Aβ oligomers induced fewer neuronal losses, when compared to wild-type (WT) mice. We conclude that endogenous DHA are neuroprotective in pathogenesis processes of AD.

Keywords

Alzheimer’s disease Aβ oligomers DHA Omega-3 Fat-1 mice 

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Yuan Tan
    • 1
  • Huixia Ren
    • 1
  • Zhe Shi
    • 1
  • Xiaoli Yao
    • 2
  • Chengwei He
    • 1
  • Jing-X Kang
    • 3
  • Jian-Bo Wan
    • 1
  • Peng Li
    • 1
  • Ti-Fei Yuan
    • 4
  • Huanxing Su
    • 1
  1. 1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical SciencesUniversity of MacauMacaoChina
  2. 2.Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated HospitalSun Yat-Sen UniversityGuangzhouChina
  3. 3.Laboratory for Lipid Medicine and Technology, The Department of MedicineMassachusetts General Hospital and Harvard Medical SchoolBostonUSA
  4. 4.School of PsychologyNanjing Normal UniversityNanjingChina

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