Fig. 5
Effects of icv STZ (bilaterally, 3 mg/kg body weight, on days 1 and 3) on concentrations of brain metabolites obtained from 1H-MRS spectra recorded from 27 μL volume comprising hippocampus and part of the cerebral cortex, in 7 T magnetic field strength with very short echo time. a 2 weeks after and b 2 months after icv STZ injection. Mac macromolecules, Asc ascorbate, Asp aspartate, Cr creatine, PCr phosphocreatine, Glc glucose, Gln glutamine, Glu glutamate, Ins inositol, Lac lactate, NAA N-acetylaspartate, NAAG N-acetylaspartylglutamate, PE phosphorylethanolamine, Tau taurine; GPC+PC glycerophosphocholine and phosphocholine, n = 8, error bars show standard deviations, asterisks indicate p < 0.05 by two-tailed t test for independent means. (Reproduced from ref. 68, with permission from Springer-Verlag)