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Molecular Neurobiology

, Volume 53, Issue 1, pp 455–471 | Cite as

The Binding Receptors of Aβ: an Alternative Therapeutic Target for Alzheimer’s Disease

  • Min Xia
  • Xiaofang Cheng
  • Ruofan Yi
  • Dong GaoEmail author
  • Jiaxiang XiongEmail author
Article

Abstract

Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders, which causes the deterioration of memory and other cognitive abilities of the elderly. Previous lines of research have shown that Aβ is an essential factor in AD pathology and the soluble oligomeric species of Aβ peptide is presumed to be the drivers of synaptic impairment in AD. However, the exact mechanisms underlying Aβ-induced synapse dysfunction are still not fully understood. Recently, increasing evidence suggests that some potential receptors which bind specifically with Aβ may play important roles in inducing the toxicity of the neurons in AD pathology. These receptors include the cellular prion protein (PrPc), the α7 nicotinic acetylcholine receptor (α7nAChR), the p75 neurotrophin receptor (p75NTR), the beta-adrenergic receptors (β-ARs), the Eph receptors, the paired immunoglobulin-like receptor B (PirB), the PirB’s human ortholog receptor (LilrB2), and the Fcγ receptor II-b (FcγRIIb). This review summarizes the characters of these prominent receptors and how the bindings of them with Aβ inhibit the LTP, decrease the number of dendritic spine, damage the neurons, and so on in AD pathogenesis. Blocking or rescuing these receptors may have significant importance for AD treatments.

Keywords

Alzheimer’s disease Amyloid-beta Binding receptors Synaptic dysfunction Dementia 

Abbreviations

Amyloid-beta

APP

Amyloid precursor protein

PrPc

Cellular prion protein

β2AR

β2 Adrenergic receptor

α7nAChR

α7 Nicotinic acetylcholine receptor

EphB2

Eph receptor B2

p75NTR

P75 neurotrophin receptor

PirB

Paired immunoglobulin-like receptor B

FcγRIIb

Fcγ receptor II-b

AMPARs

AMPA subtype glutamate receptors

NMDAR

N-methyl-d-aspartate receptors

ERK

Extracellular signal-regulated kinase

MAPK

Mitogen-activated protein kinase

PKA

Protein kinase A

JNK

c-Jun N-terminal kinase

CREB protein

cAMP regulatory element-binding protein

eEF2

Eukaryotic elongation factor 2

Notes

Acknowledgments

We thank Zhongxiang Yao, Xiaowei Chen, Kan Li, and Jia Lou for their help in making suggestions and designing figures. This work was supported by grants from the National Natural Science Foundation of China (no. 81271463 and no. 81371457), as well as the High Education Teaching Reform Project of Chongqing (no. 132080).

Conflict of Interest

The authors declare no conflict of interest.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of PhysiologyThird Military Medical UniversityChongqingChina
  2. 2.Department of Sleep and PsychologyInstitute of Surgery Research, Daping Hospital, Third Military Medical UniversityChongqingChina

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