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RETRACTED ARTICLE: The Impact of Survivin on Prognosis and Clinicopathology of Glioma Patients: A Systematic Meta-Analysis

Molecular Neurobiology volume 51, pages 1462–1467 (2015)Cite this article

This article was retracted on 16 January 2017

Abstract

Up to now, survivin has been recommended as a prognostic and diagnostic indicator in glioma patients. However, there are still many controversies. Here, a meta-analysis was conducted to draw a more definitive conclusion on the correlation of survivin with overall survival (OS), age, gender, and WHO grade. Eligible studies were available through careful assessment, and then pooled hazard ratios (HRs) or odds ratios (ORs) with 95 % confidence intervals (95 % CIs) were estimated. Funnel plots were introduced to evaluate the publication bias. Additionally, heterogeneity and sensitivity were also evaluated. In the present meta-analysis, 15 eligible studies with a total of 1,089 patients were incorporated. Survivin expression in gliomas correlated with 2-year OS (n = 8; HR 0.17, 95 % CI 0.11–0.26) and 5-year OS (n = 7; HR 0.12, 95 % CI 0.07–0.22) in patients. In addition, a fixed-effect model revealed a significant association between survivin and age (male/+; OR 2.10, 95 % CI 1.44–3.05) and survivin and WHO grade (I+II/+; OR 0.27, 95 % CI 0.19–0.38). No heterogeneity was observed across all studies. According to Begg’s and Egger’s test and funnel plot, no publication bias was reported. Taken together, our meta-analysis suggests that survivin expression is associated with poor survival, older age, and higher WHO grade and could be suggested as a useful prognostic and diagnostic biomarker, or an effective therapy target.

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Acknowledgments

This study was supported by Shandong University Science Technology Innovation Foundation (201410422123). We greatly thank Ruiyang Yi in Sandy lab for valuable suggestions and writing.

Disclosure

The authors state that there are no conflicts of interest to disclose.

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Affiliations

  1. Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China

    Shunzeng Lv, Congxin Dai, Bowen Sun & Renzhi Wang

  2. Shandong University School of Medicine, Jinan, Shandong, China

    Shunzeng Lv, Ranran Shi, Zhenyu Tang, Mingzhi Han & Ruixiang Bian

  3. Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

    Yuting Liu

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  1. Shunzeng Lv
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  2. Congxin Dai
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Corresponding author

Correspondence to Renzhi Wang.

Additional information

Shunzeng Lv and Congxin Dai contributed equally to this work.

An erratum to this article is available at http://dx.doi.org/10.1007/s12035-017-0402-0.

This article has been retracted at the request of the Editor-in-Chief and the Publisher. The article shows evidence of irregularities in authorship during the submission process. There is strong reason to believe that the peer review process was compromised and the authors have plagiarized parts from the following article:

Shunzeng Lv, Ekaterina Turlova, Shigang Zhao, Huihui Kang, Mingzhi Han, Hong-Shuo Sun, Prognostics and clinicopathological significance of survivin expression in bladder cancer patients: a meta-analysis. Tumor Biol. (2014) 35: 1565. doi:10.1007/s13277-013-1216-y Received: 23 July 2013

In addition, the article shows similarities with the following article which was submitted within a close timeframe:

Xiangshan Yang, Shunzeng Lv, Yuting Liu, Daotang Li, Ranran Shi, Zhenyu Tang, Jianzhen Fan, Zhongfa Xu, The Clinical Utility of Matrix Metalloproteinase 9 in Evaluating Pathological Grade and Prognosis of Glioma Patients: A Meta-Analysis. Mol Neurobiol (2015) 52: 38. doi:10.1007/s12035-014-8850-2 Received: 20 July 2014

The article “The impact of survivin on prognosis and clinicopathology of glioma patients: a systematic meta-analysis” was received on 26 June 2014.

As such the validity of the content of this article cannot be verified.

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Lv, S., Dai, C., Liu, Y. et al. RETRACTED ARTICLE: The Impact of Survivin on Prognosis and Clinicopathology of Glioma Patients: A Systematic Meta-Analysis. Mol Neurobiol 51, 1462–1467 (2015). https://doi.org/10.1007/s12035-014-8823-5

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  • DOI: https://doi.org/10.1007/s12035-014-8823-5

Keywords

  • Survivin
  • Gliomas
  • Prognosis
  • Clinicopathology
  • Meta-analysis