Molecular Neurobiology

, Volume 49, Issue 1, pp 590–600

Exosomes: Mediators of Neurodegeneration, Neuroprotection and Therapeutics


DOI: 10.1007/s12035-013-8544-1

Cite this article as:
Kalani, A., Tyagi, A. & Tyagi, N. Mol Neurobiol (2014) 49: 590. doi:10.1007/s12035-013-8544-1


Exosomes have emerged as prominent mediators of neurodegenerative diseases where they have been shown to carry disease particles such as beta amyloid and prions from their cells of origin to other cells. Their simple structure and ability to cross the blood–brain barrier allow great opportunity to design a “makeup” with drugs and genetic elements, such as siRNA or miRNA, and use them as delivery vehicles for neurotherapeutics. Their role in neuroprotection is evident by the fact that they are involved in the regeneration of peripheral nerves and repair of neuronal injuries. This review is focused on the role of exosomes in mediating neurodegeneration and neuroprotection.


Blood–brain barrier Exosomes Neurotherapeutics Neurodegeneration 

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Physiology and Biophysics, School of Medicine, Health Sciences Center, A-1201University of LouisvilleLouisvilleUSA

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