Molecular Neurobiology

, Volume 45, Issue 3, pp 605–620 | Cite as

Role of Dopamine Receptors in ADHD: A Systematic Meta-analysis

  • Jing Wu
  • Haifan Xiao
  • Hongjuan Sun
  • Li Zou
  • Ling-Qiang ZhuEmail author


The dopaminergic system plays a pivotal role in the central nervous system via its five diverse receptors (D1–D5). Dysfunction of dopaminergic system is implicated in many neuropsychological diseases, including attention deficit hyperactivity disorder (ADHD), a common mental disorder that prevalent in childhood. Understanding the relationship of five different dopamine (DA) receptors with ADHD will help us to elucidate different roles of these receptors and to develop therapeutic approaches of ADHD. This review summarized the ongoing research of DA receptor genes in ADHD pathogenesis and gathered the past published data with meta-analysis and revealed the high risk of DRD5, DRD2, and DRD4 polymorphisms in ADHD.


ADHD Dopamine receptor Meta-analysis 



The manuscript is supported by the National Nature Science Foundation of China (NSFC) (81101016), New Century Excellent Talents in University (NCET-10-0421), and the Ministry of Science and Technology of China (2011DFG33250).

Conflicts of interest

The authors declared no conflicts of interest.

Supplementary material

12035_2012_8278_MOESM1_ESM.doc (472 kb)
ESM 1 (DOC 471 kb)


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Jing Wu
    • 1
  • Haifan Xiao
    • 1
  • Hongjuan Sun
    • 1
  • Li Zou
    • 1
  • Ling-Qiang Zhu
    • 2
    Email author
  1. 1.Department of Epidemiology and Biostatistics and Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina
  2. 2.Department of Pathophysiology and Key Lab of Neurological Disease of Education Ministry, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

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