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Electrophysiological Analysis of Circuits Controlling Energy Homeostasis

Molecular Neurobiology volume 45, pages 258–278 (2012)Cite this article

Abstract

Since the discovery of leptin and the central melanocortin circuit, electrophysiological studies have played a major role in elucidating mechanisms underlying energy homeostasis. This review highlights the contribution of findings made by electrophysiological measurements to the current understanding of hypothalamic neuronal networks involved in energy homeostasis with a specific focus on the arcuate–paraventricular nucleus circuit.

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Acknowledgments

I am greatly thankful to Drs. Amanda Vanhoose, Roger D Cone, Benjamin Renquist, and David Jacobson for their assistance in preparation of this manuscript.

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  1. Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA

    Masoud Ghamari-Langroudi

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  1. Masoud Ghamari-Langroudi
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Correspondence to Masoud Ghamari-Langroudi.

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Ghamari-Langroudi, M. Electrophysiological Analysis of Circuits Controlling Energy Homeostasis. Mol Neurobiol 45, 258–278 (2012). https://doi.org/10.1007/s12035-012-8241-5

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  • DOI: https://doi.org/10.1007/s12035-012-8241-5

Keywords

  • Neuronal network
  • Feeding behavior
  • Hypothalamus
  • Peripheral metabolic signals
  • Membrane current
  • Intracellular signaling molecules
  • Adiposity signals
  • Electrophysiological tools
  • Leptin
  • Insulin
  • Ghrelin
  • PYY(3–36)
  • Orexin
  • Neuropeptides