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Modulation of Myelin Basic Protein Gene Expression by Acetyl-l-Carnitine

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Abstract

Acetyl-l-carnitine (ALC), the acetyl ester of l-carnitine, is a naturally occurring molecule which plays an essential role in intermediary and mitochondrial metabolism. It has also neurotrophic and antioxidant actions, demonstrating efficacy and high tolerability in the treatment of neuropathies of various etiologies. ALC is a molecule of considerable interest for its clinical application in various neural disorders, although little is known regarding its effects on gene expression. Suppression subtractive hybridization methodology was used for the generation of subtracted complementary DNA libraries and the subsequent identification of differentially expressed transcripts in the rat brain after chronic ALC treatments. We provided evidence for a downregulation of the expression of all of the isoforms of myelin basic protein gene following prolonged ALC treatment, indicating a possible role in the modulation of myelin basic protein turnover, stabilizing and maintaining myelin integrity.

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Authors and Affiliations

  1. Department of Economics and Food Sciences, University of Perugia, Via San Costanzo, 06126, Perugia, Italy

    Giovanna Traina

  2. Department of Biology, Unit of General Physiology, University of Pisa, Pisa, Italy

    Giuseppe Federighi, Monica Macchi & Marcello Brunelli

  3. Department of Agricultural Plant Biology, Genetic Section, University of Pisa, Pisa, Italy

    Rodolfo Bernardi & Mauro Durante

Authors
  1. Giovanna Traina
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  2. Giuseppe Federighi
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  3. Monica Macchi
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  4. Rodolfo Bernardi
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  5. Mauro Durante
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  6. Marcello Brunelli
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Correspondence to Giovanna Traina.

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Traina, G., Federighi, G., Macchi, M. et al. Modulation of Myelin Basic Protein Gene Expression by Acetyl-l-Carnitine. Mol Neurobiol 44, 1–6 (2011). https://doi.org/10.1007/s12035-011-8189-x

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  • DOI: https://doi.org/10.1007/s12035-011-8189-x

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