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The Role of Notch Signaling in Adult Neurogenesis

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Abstract

Neurogenesis occurs throughout adulthood in the mammalian brain. Newly born neurons are incorporated into the functional networks of both the olfactory bulb and the hippocampal dentate gyrus, and there is growing evidence that adult neurogenesis is important for various brain functions. Continuous neurogenesis is achieved by the coordinated proliferation and differentiation of adult neural stem cells. In this review, we discuss the recent findings concerning the roles of Notch signaling in adult neural stem cells.

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Acknowledgments

This work was supported by the grants-in-aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan. I.I. was supported by JST PRESTO program.

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Authors and Affiliations

  1. Institute for Virus Research, Kyoto University, Shogoin-Kawahara, Sakyo-ku, Kyoto, 606-8507, Japan

    Itaru Imayoshi & Ryoichiro Kageyama

  2. The Hakubi Center, Kyoto University, Kyoto, 606-8507, Japan

    Itaru Imayoshi

  3. Japan Science and Technology Agency, Precursory Research for Embryonic Science and Technology (PRESTO), Kyoto, 606-8507, Japan

    Itaru Imayoshi

  4. Japan Science and Technology Agency, Core Research for Evolutional Science and Technology (CREST), Kyoto, 606-8507, Japan

    Ryoichiro Kageyama

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  1. Itaru Imayoshi
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  2. Ryoichiro Kageyama
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Correspondence to Itaru Imayoshi or Ryoichiro Kageyama.

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Imayoshi, I., Kageyama, R. The Role of Notch Signaling in Adult Neurogenesis. Mol Neurobiol 44, 7–12 (2011). https://doi.org/10.1007/s12035-011-8186-0

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