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Activity-Dependent Dendritic Release of BDNF and Biological Consequences

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Abstract

Network construction and reorganization is modulated by the level and pattern of synaptic activity generated in the nervous system. During the past decades, neurotrophins, and in particular brain-derived neurotrophic factor (BDNF), have emerged as attractive candidates for linking synaptic activity and brain plasticity. Thus, neurotrophin expression and secretion are under the control of activity-dependent mechanisms and, besides their classical role in supporting neuronal survival neurotrophins, modulate nearly all key steps of network construction from neuronal migration to experience-dependent refinement of local connections. In this paper, we provide an overview of recent findings showing that BDNF can serve as a target-derived messenger for activity-dependent synaptic plasticity and development at the single cell level.

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Acknowledgments

This work was supported by INSERM, CNRS and ANR (Agence Nationale pour la Recherche) and the DFG (SFB 553), Stiftung Rheinland-Pfalz and the Schram-Stiftung. N.K. was a recipient of a FRM (Fondation pour la Recherche Médicale) and ANR fellowships.

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  1. INMED (Institut de Neurobiologie de la Méditerranée), INSERM (Institut National de la Santé et de la Recherche Médicale Unité 901), Université de La Méditerranée, Parc scientifique de Luminy, BP 13, 13273, Marseille Cedex 09, France

    Nicola Kuczewski, Christophe Porcher, Igor Medina & Jean-Luc Gaiarsa

  2. Institute of Physiology, Otto-von-Guericke-University, Magdeburg, Germany

    Volkmar Lessmann

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  1. Nicola Kuczewski
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Correspondence to Nicola Kuczewski.

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Kuczewski, N., Porcher, C., Lessmann, V. et al. Activity-Dependent Dendritic Release of BDNF and Biological Consequences. Mol Neurobiol 39, 37–49 (2009). https://doi.org/10.1007/s12035-009-8050-7

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