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Highly conductive multiscale fibre-engineered biomedical patch prepared by electrospinning substrate and in-situ polymerization

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Abstract

Myocardial infarction (MI) is one of the major diseases that threaten human life and health. The construction of cardiac patch by tissue engineering method and biomaterials is a promising way to treat MI clinically by improving electromechanical signal transduction in MI area. A highly conductive electrospun fibre-engineered biomedical patch with porous structure, mechanical support and conductive property was prepared by poly(lactic-co-glycolic acid) (PLGA), polyaniline (PANI), graphene oxide (GO) and multi-walled carbon nanotubes (MWCNT). PLGA, PLGA/MWCNT, PLGA/GO electrospinning fibre membrane substrates were prepared first and then in-situ polymerization of aniline (ANI) to form PANI/PLGA and PANI/PLGA/MWCNT fibre conductive patches. PLGA-blended fibre patch had a smooth fibre surface and an uniform fibre diameter, porous structure, fibre parallel arrangement, in which PLGA/MWCNT had larger ultimate strength and Young’s modulus. When the ANI concentration was 0.4 mol l−1, electrical conductivity reached the maximum value, and the electrical conductivity of PANI/PLGA fibre patch was significantly larger than that of PANI/PLGA/MWCNT fibre patch as the ANI concentration increased, which were 1.56 × 10−2 and 6.06 × 10−3 S cm−1, respectively. Highly conductive fibre membrane-engineered biomedical patch had excellent electrical and thermal stability, and improved signal transduction, with porous structure and mechanical support for potential MI repair.

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Acknowledgements

This research was supported by the Zhejiang Provincial Natural Science Foundation of China, under Grant No. LY20E030004, and the Fundamental Research Funds of the Zhejiang Sci-Tech University, under Grant No. 23202132-Y.

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Authors and Affiliations

  1. College of Textile Science and Engineering (International Institute of Silk), Zhejiang Sci-Tech University, Hangzhou, 310018, China

    Jianyong Feng, Qian Lin, Wenjie Wang & Chenjie Meng

  2. Key Laboratory of Intelligent Textile and Flexible Interconnection of Zhejiang Province, Hangzhou, 310018, China

    Jianyong Feng

  3. Cavendish Laboratory, University of Cambridge, Cambridge, CB3 0HE, UK

    Jianyong Feng

  4. Zhejiang Barty Medical Technology Co., Ltd., Yinhai Scientific Innovation Center, Hangzhou, 310018, China

    Ruilin Du

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  1. Jianyong Feng
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  2. Qian Lin
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  5. Ruilin Du
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Correspondence to Jianyong Feng.

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Feng, J., Lin, Q., Wang, W. et al. Highly conductive multiscale fibre-engineered biomedical patch prepared by electrospinning substrate and in-situ polymerization. Bull Mater Sci 47, 101 (2024). https://doi.org/10.1007/s12034-024-03155-x

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  • DOI: https://doi.org/10.1007/s12034-024-03155-x

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