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Pd-Co3O4-based nanostructures for the development of enzyme-free glucose sensor

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Abstract

In this study, we report enzyme-free glucose sensors based on palladium (Pd) nanoparticles deposited onto Co3O4 nanostructures. A simple, low-temperature aqueous method was used for the fabrication of Co3O4 nanostructures. Then, Pd nanoparticles were decorated onto Co3O4 nanostructures using the ultraviolet reduction method. Morphology, elemental composition and crystalline features of the proposed composite nanostructures were investigated by powder X-ray diffraction, scanning electron microscopy and energy dispersive spectroscopy techniques. Cyclic voltammetry and linear sweep voltammetry were used to investigate the electrochemical behaviour of Pd–Co3O4 nanostructures during glucose sensing. The proposed nanostructures showed excellent electrochemical activity for the quantitative detection of glucose at a potential of 0.6 V vs. Ag/AgCl. Importantly, the fabricated enzyme-free glucose sensor shows a linear response over the range of 1–6.0 mM glucose, with a limit of detection of 0.01 mM. The interference study was also carried out to probe the selectivity of Pd–Co3O4 nanostructures towards glucose detection in the presence of different interfering substances. The combined results attest that the as-synthesized Pd–Co3O4 nanostructures are highly stable and selective for the detection of glucose, suggesting their great potential for the quantitative determination of glucose in different biological fluids.

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Acknowledgements

This work was funded via Researchers Supporting Project number (RSP-2022/79) at King Saud University, Riyadh, Saudi Arabia. We also thank the British University in Egypt for the support in SEM imaging through the Nanotechnology Research Centre.

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Authors and Affiliations

  1. Institute of Chemistry, University of Sindh, Jamshoro, 76080, Pakistan

    Abdul Sattar Chang, Aneela Tahira, Fouzia Chang & Zafar Hussain Ibupoto

  2. Department of Chemical Engineering, Mehran University of Engineering and Technology, Jamshoro, 76020, Pakistan

    Zulifqar Ali Solangi

  3. Institute of Chemistry, Shah Abdul Latif University, Khairpur Mirs, 66111, Pakistan

    Abdul Ghaffar Solangi

  4. Department of Zoology, Shah Abdul Latif University, Khairpur Mirs, 66111, Pakistan

    Mazhar Hussain Ibupoto

  5. Department of Science and Technology, Campus Norrköping, Linköping University, SE-60174, Norrköping, Sweden

    Shymaa S Medany & Magnus Willander

  6. Department of Chemistry, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia

    Ayman Nafady

  7. Nanotechnology Research Centre (NTRC), The British University in Egypt (BUE), Cairo, 11837, Egypt

    Amal Kasry

  8. Chemistry Department, Faculty of Science, Cairo University, Giza, 12613, Egypt

    Shymaa S Medany

Authors
  1. Abdul Sattar Chang
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  2. Aneela Tahira
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  3. Zulifqar Ali Solangi
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  4. Abdul Ghaffar Solangi
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  6. Fouzia Chang
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Correspondence to Zafar Hussain Ibupoto.

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Chang, A.S., Tahira, A., Solangi, Z.A. et al. Pd-Co3O4-based nanostructures for the development of enzyme-free glucose sensor. Bull Mater Sci 45, 62 (2022). https://doi.org/10.1007/s12034-021-02642-9

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