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Injectable nanocurcumin-dispersed gelatin–pluronic nanocomposite hydrogel platform for burn wound treatment

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Abstract

To utilize the potent pharmaceutical properties of curcumin (Cur) and gelatin-based materials in tissue regeneration, we fabricated a thermosensitive nanocomposite hydrogel based on pluronic-grafted gelatin (PG) and nanocurcumin (nCur) to enhance burn healing. In this method, the amphiphilic PG played a role as a surfactant to prepare and protect nanosized Cur particles, which could overcome the poor dissolution of the phytochemical. The synthesized PG was identified by \(^{1}\hbox {H}\) nuclear magnetic resonance. Depending on the amount of Cur, size distribution of the dispersed nCur ranged from 1.5 ± 0.5 to 16 ± 3.2 nm as observed using transmission electron microscopy and dynamic light scattering. The nCur-dispersed PG solution formed nCur–PG nanocomposite hydrogel on warming up to \(35{^{\circ }}\hbox {C}\). Release profile indicated sustainable release of Cur from the injectable platform. Fibroblast cells were well proliferated on the nanocomposite hydrogel. The nCur–PG enhanced the healing process of second-degree burn wound. These results showed potential applications of the biomaterial in tissue regeneration.

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Acknowledgements

This work was financially supported by Tra Vinh University under grant number 1434/HD.DHTV-KHCN and Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.02-2017.60.

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Author notes

  1. First two authors contributed equally to this study.

Authors and Affiliations

  1. School of Biotechnology, International University, National Universities in HCMC, 70000, Ho Chi Minh City, Viet Nam

    Le Hang Dang & Ngoc Oanh Pham

  2. Graduate University of Science and Technology, Ho Chi Minh City, 700000, Viet Nam

    Le Hang Dang, Van Thoai Dinh, Van Thu Le & Ngoc Quyen Tran

  3. Institute of Applied Materials Science, Viet Nam Academy of Science and Technology, Ho Chi Minh City, 700000, Viet Nam

    Ngoc Trinh Huynh, Ngoc Oanh Pham, Cong Truc Nguyen, Van Thu Le & Ngoc Quyen Tran

  4. Faculty of Chemistry, Tra Vinh University, Tra Vinh Province, 940000, Viet Nam

    Ngoc Trinh Huynh

  5. Institute of Chemistry and Materials, 17 Hoang Sam 100000, Cau Giay, Ha Noi, Viet Nam

    Minh Thanh Vu

  6. NTT Hi-Tech Institute, Nguyen Tat Thanh University, District 4, Ho Chi Minh City, 700000, Viet Nam

    Van Thoai Dinh & Ngoc Quyen Tran

Authors
  1. Le Hang Dang
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  2. Ngoc Trinh Huynh
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  3. Ngoc Oanh Pham
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Correspondence to Ngoc Quyen Tran.

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Dang, L.H., Huynh, N.T., Pham, N.O. et al. Injectable nanocurcumin-dispersed gelatin–pluronic nanocomposite hydrogel platform for burn wound treatment. Bull Mater Sci 42, 71 (2019). https://doi.org/10.1007/s12034-019-1745-0

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  • DOI: https://doi.org/10.1007/s12034-019-1745-0

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