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Nanogels of acetylated ulvan enhance the solubility of hydrophobic drug curcumin

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Abstract

Curcumin (Cur) is a polyphenol showing various bioactivities including anti-tumour activity. However, poor solubility of Cur in aqueous solution is a major barrier to its bioavailability and clinical efficacy. In this study, hydrophobically modified ulvan was considered to self-assemble to fabricate nanogels. This is a network of hydrophilic segments with hydrophobic microdomains in the nanopores, which keeps Cur from dispersing into the media and raise Cur solubility in water by 20,000 times. A Cur-loaded acetylated ulvan nanogel was characterized by scanning electron microscopy, transmission electron microscopy and dynamic light scattering. This result confirmed that hydrophobically modified ulvan could be used as a self-organizing assembly nanogel to carry and deliver water-insoluble bioactive compounds.

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Acknowledgements

This research is funded by the Vietnam Academy of Science and Technology (Project number VAST03.04/15-16).

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Authors and Affiliations

  1. Nhatrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, Nha Trang, 57000, Vietnam

    Truong Hai Bang, Tran Thi Thanh Van, Bui Minh LY & Nguyen Duy Nhut

  2. Institute of Research and Development, Duy Tan University, Da Nang, 50000, Vietnam

    Le Xuan Hung & Bui The Huy

  3. Institute of Chemistry, Vietnam Academy of Science and Technology, Cau Giay Hanoi, 10072, Vietnam

    Thanh Thuy Thu Thuy

  4. Department of Chemistry, Changwon National, Changwon, 51140, Republic of Korea

    Bui The Huy

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  1. Truong Hai Bang
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  2. Tran Thi Thanh Van
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  5. Nguyen Duy Nhut
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Correspondence to Truong Hai Bang.

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Bang, T.H., Van, T.T.T., Hung, L.X. et al. Nanogels of acetylated ulvan enhance the solubility of hydrophobic drug curcumin. Bull Mater Sci 42, 1 (2019). https://doi.org/10.1007/s12034-018-1682-3

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  • DOI: https://doi.org/10.1007/s12034-018-1682-3

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