Skip to main content

Advertisement

SpringerLink
Log in

A hybrid system: MnO-incorporated mesoporous silica nanoparticles for theranostic applications

  • Published:
Bulletin of Materials Science Aims and scope Submit manuscript

Abstract

The need for an alternative \({ T}_{1}\) contrast enhancer for magnetic resonance imaging (MRI) has been escalating owing to the toxicity profiles observed with the use of commercial contrast agents. Manganese oxide nanoparticles provide an optimal solution for the problem, as it is an endogenous co-factor for many enzymes in the biological system. In the present work, we have synthesized mesoporous silica nanoparticles encapsulated with manganese oxide nanoparticles as a positive contrast enhancer for MRI applications. Spherical magnetic MnO nanoparticles with divalent oxidation state were also synthesized and utilized as control to compare the efficiency of the nano-hybrid system. MRI showed higher contrast enhancement with the use of nano-hybrid and the relaxivity value for \({ T}_{1}\)-weighted imaging was calculated to be \(2.6~\hbox {mg ml}^{-1}~\hbox {s}^{-1}\). Also, the developed system was validated for its usefulness as a therapeutic system through adsorption studies. Therefore, the nano-hybrid has the potential to be a competent MRI contrast enhancer that could be used for theranostic applications.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10
Fig. 11
Fig. 12
Fig. 13

Similar content being viewed by others

References

  1. Berger A 2002 Br. Med. J. 324 35

    Article  Google Scholar 

  2. Chaughule R S, Purushotham S and Ramanujan R V 2012 Proc. Natl. Acad. Sci. 82 257

    CAS  Google Scholar 

  3. Estelrich J, Sánchez-Martín M J and Busquets M A 2015 Int. J. Nanomed. 10 1727

    CAS  Google Scholar 

  4. Gao H, Liu X, Tang W, Niu D, Zhou B, Zhang H et al 2016 Nanoscale 8 19573

    Article  CAS  Google Scholar 

  5. Gao Z, Ma T, Zhao E, Docter D, Yang W, Stauber R H et al 2016 Small 12 556

    Article  CAS  Google Scholar 

  6. Guillet-Nicolas R, Laprise-Pelletier M, Nair M M, Chevallier P, Lagueux J, Gossuin Y et al 2013 Nanoscale 5 11499

    Article  CAS  Google Scholar 

  7. Kim J, Piao Y and Hyeon T 2009 Chem. Soc. Rev. 38 372

    Article  CAS  Google Scholar 

  8. Lee S H, Kim B H, Na H B and Hyeon T 2014 Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 6 196

    Article  CAS  Google Scholar 

  9. Liu X, Chen C, Zhao Y and Jia B 2013 J. Nanomater. 2013 1

    Google Scholar 

  10. Ramalho J, Ramalho M, Jay M, Burke L M and Semelka R C 2016 Magn. Reson. Imaging 34 1394

    Article  CAS  Google Scholar 

  11. Semelka R C, Ramalho M and Jay M 2016 Magn. Reson. Imaging 34 1399

    Article  Google Scholar 

  12. Wang A, Guo M, Wang N, Zhao J, Qi W, Muhammad F et al 2014 Nanoscale 6 5270

    Article  CAS  Google Scholar 

  13. Wang P, Yang J, Zhou B, Hu Y, Xing L, Xu F et al 2016 ACS Appl. Mater. Interfaces 9 47

    Article  Google Scholar 

  14. Xu W, Kattel K, Park J Y, Chang Y, Kim T J and Lee G H 2012 Chem. Phys. 14 12687

    CAS  Google Scholar 

  15. Pourmortazavi S M, Rahimi-Nasrabadi M, Davoudi-Dehaghani A A, Javidan A, Zahedi M M and Hajimirsadeghi S S 2012 Mater. Res. Bull. 47 1045

    Article  CAS  Google Scholar 

  16. Murugan B, Ramana L N, Gandhi S, Sethuraman S and Krishnan U M 2013 J. Mater. Chem. B 1 3494

    Article  CAS  Google Scholar 

  17. Park M, Lee N, Choi S H, An K, Yu S H, Kim J H et al 2011 Chem. Mater. 23 3318

    Article  CAS  Google Scholar 

  18. Pinc J, Jankovský O and Bart\(\mathring{\rm u}\)něk V 2017 Chem. Pap. 71 1031

  19. Xiao J, Tian X M, Yang C, Liu P, Luo N Q, Liang Y et al 2013 Sci. Rep. 3 3424

    Article  CAS  Google Scholar 

  20. Li J, Wu C, Hou P, Zhang M and Xu K 2018 Biosens. Bioelectron. 102 1

    Article  CAS  Google Scholar 

  21. Schladt T D, Koll K, Prüfer S, Bauer H, Natalio F, Dumele O et al 2012 J. Mater. Chem. 22 9253

    Article  CAS  Google Scholar 

  22. Chen N, Shao C, Qu Y, Li S, Gu W, Zheng T et al 2014 ACS Appl. Mater. Interfaces 22 19850

    Article  Google Scholar 

  23. Yang H, Zhuang Y, Hu H, Du X, Zhang C, Shi X et al 2010 Adv. Funct. Mater. 11 1733

    Article  Google Scholar 

  24. Chen F, Zhao Y, Pan Y, Xue X, Zhang X, Kumar A et al 2015 Mol. Pharm. 12 2237

    Article  CAS  Google Scholar 

  25. Kim T, Momin E, Choi J, Yuan K, Zaidi H, Kim J et al 2011 J. Am. Chem. Soc. 133 2955

    Article  CAS  Google Scholar 

  26. Gandhi S, Venkatesh S, Sharma U, Jagannathan N R, Sethuraman S and Krishnan U M 2011 J. Mater. Chem. 21 1569

    Article  Google Scholar 

  27. Hsu B Y, Ng M, Zhang Y, Wong S Y, Bhakoo K, Li X et al 2015 Adv. Funct. Mater. 25 5269

    Article  CAS  Google Scholar 

  28. Shin J, Anisur R M, Ko M K, Im G H, Lee J H and Lee I S 2009 Angew. Chem. Int. Ed. 48 321

    Article  CAS  Google Scholar 

  29. Niu D, Luo X, Li Y, Liu X, Wang X and Shi J 2013 ACS Appl. Mater. Interfaces 5 9942

    Article  CAS  Google Scholar 

  30. Hu H, Dai A, Sun J, Li X, Gao F, Wu L et al 2013 Nanoscale 5 10447

    Article  CAS  Google Scholar 

  31. Largitte L and Pasquier R 2016 Chem. Eng. Res. Des. 109 495

    Article  CAS  Google Scholar 

  32. Ho Y S and McKay G 2002 Adsorp. Sci. Technol. 20 797

    Article  CAS  Google Scholar 

  33. Ayawei N, Ebelegi A N and Wankasi D 2017 J. Chem. 2017 1

    Article  Google Scholar 

Download references

Acknowledgements

We wish to acknowledge Nano Mission Council, DST (DST/INT/JSPS/P-221/2016) and SASTRA Deemed University for the financial and infrastructural support.

Author information

Authors and Affiliations

  1. Centre for Nanotechnology and Advanced Biomaterials, SASTRA Deemed to be University, Thanjavur, 613 401, India

    Varuna Kumaravel, Kartikeyan Damodaran, Sakthivel Gandhi & Uma Maheswari Krishnan

  2. Department of Chemistry, SASTRA Deemed to be University, Thanjavur, 613 401, India

    Sakthivel Gandhi & Uma Maheswari Krishnan

Authors
  1. Varuna Kumaravel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kartikeyan Damodaran
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sakthivel Gandhi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Uma Maheswari Krishnan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Uma Maheswari Krishnan.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kumaravel, V., Damodaran, K., Gandhi, S. et al. A hybrid system: MnO-incorporated mesoporous silica nanoparticles for theranostic applications. Bull Mater Sci 41, 133 (2018). https://doi.org/10.1007/s12034-018-1646-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s12034-018-1646-7

Keywords

Search

Navigation